Evidence map›Paper›PMID 41774040›Full record

Trial reportJournal of child psychology and psychiatry, and allied disciplines2026

Outcome and cost-effectiveness of transdiagnostic cognitive behavioral therapy compared with management as usual for youth with common mental health problems: Long-term results from the Mind-My-Mind randomized trial.

Ditte Vassard, Martin Køster Rimvall, Rasmus Trap Wolf, Robin Christensen, Sabrina M Nielsen, Kerstin Jessica Plessen, Frank Verhulst, Niels Bilenberg, Per Hove Thomsen, Mikael Thastum and 5 more

Registry-linked trialAbstract readPragmatic Clinical TrialMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of child psychology and psychiatry, and allied disciplines, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04804917 (Long-term Outcome of a Transdiagnostic Cognitive-behavioral Psychotherapy Compared With Management as Usual for Youth With Common Mental Health Problems), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04804917 completednot on this map

Long-term Outcome of a Transdiagnostic Cognitive-behavioral Psychotherapy Compared With Management as Usual for Youth With Common Mental Health Problems: a 3-year Follow-up of a Randomized Clinical Trial

TypeobservationalSponsorMental Health Centre Copenhagen, Bispebjerg and Frederiksberg HospitalRan2021 to 2021Enrolled396ConditionsEmotional Problem, Anxiety Disorder of Childhood, Depressive Symptoms, Behavior Problem of Childhood and Adolescence
3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Ditte VassardChild and Adolescent Mental Health Center, Copenhagen University Hospital - Mental Health Services CPH, Copenhagen, Denmark.ORCID 0000-0001-6298-4146
Martin Køster RimvallChild and Adolescent Mental Health Center, Copenhagen University Hospital - Mental Health Services CPH, Copenhagen, Denmark.ORCID 0000-0003-2627-5523
Rasmus Trap WolfChild and Adolescent Mental Health Center, Copenhagen University Hospital - Mental Health Services CPH, Copenhagen, Denmark.
Robin ChristensenSection for Biostatistics and Evidence-Based Research, The Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.
Sabrina M NielsenSection for Biostatistics and Evidence-Based Research, The Parker Institute, Bispebjerg and Frederiksberg Hospital, Copenhagen, Denmark.
Kerstin Jessica PlessenChild and Adolescent Mental Health Center, Copenhagen University Hospital - Mental Health Services CPH, Copenhagen, Denmark.
Frank VerhulstChild and Adolescent Mental Health Center, Copenhagen University Hospital - Mental Health Services CPH, Copenhagen, Denmark.
Niels BilenbergDepartment for Child and Adolescent Psychiatry, Mental Health Services in the Region of Southern Denmark, Odense, Denmark.
Per Hove ThomsenResearch Center at Department for Child and Adolescent Psychiatry, Aarhus University Hospital, Skejby, Denmark.
Mikael ThastumDepartment of Psychology and Behavioural Science, Aarhus University, Aarhus, Denmark.
Simon-Peter NeumerCentre for Child and Adolescent Mental Health, Oslo, Norway.
Anne Katrine PagsbergChild and Adolescent Mental Health Center, Copenhagen University Hospital - Mental Health Services CPH, Copenhagen, Denmark.
Wendy K SilvermanAnxiety and Mood Disorders Program, Yale Child Study Center, Yale University School of Medicine, New Haven, Connecticut, USA.
Christoph U CorrellDepartment of Psychiatry and Molecular Medicine, Donald and Barbara Zucker School of Medicine at Hofstra/Northwell, Hempstead, New York, USA.
Pia JeppesenDepartment of Child and Adolescent Psychiatry, Copenhagen University Hospital - Psychiatry Region Zealand, Roskilde, Denmark.

Funding

Danish Foundation TrygFondenLundbeck Foundation
6 · The paper itself

Abstract

backgroundCredible long-term outcomes from randomized trials evaluating the effectiveness and cost-effectiveness of preventive programs for mental health problems are needed. We compared long-term effects of the Mind My Mind (MMM) transdiagnostic cognitive behavioral therapy (CBT) program to management as usual (MAU).

methodsThe study was a pragmatic, multisite, randomized superiority trial (2017-2019) involving youths aged 6-16 years with anxiety, depressive symptoms, and/or behavioral disturbances, recruited through family self-referral. The MMM intervention included 9-13 weekly CBT sessions. The primary outcome was change from baseline in parent-reported impact of mental health problems at 3-year follow-up post-randomization using the Strengths and Difficulties Questionnaire (SDQ) impact scale. Register-based outcomes tracked youths' psychiatric diagnoses in mental health services. To assess cost-effectiveness, we calculated the incremental costs and incremental quality-adjusted life years (QALYs). All primary analyses followed the intention-to-treat (ITT) approach. CLINICAL TRIALS REGISTRATION: ID NCT04804917.

resultsAmong 396 youths randomized (baseline mean [SD] age, 10.3 [2.4] years; 52.0% boys; MMM n = 197, MAU n = 199), the 3-year follow-up (median 167 weeks; range 124-203 weeks) primary outcome data were available in 69.0% and 59.3%, respectively. The decrease in SDQ-impact-score from baseline to 3-year follow-up (4.12→1.79 points [MMM] and 4.21→1.85 [MAU]) was similar (between-group difference, 0.06 [95% CI -0.41 to 0.52]; p = .81). An equal proportion (25%) of youths in MMM and MAU were diagnosed with any mental disorder during follow-up (HR 1.01, 95% CI 0.68-1.50). Total costs over the intervention period were higher in the MMM group (incremental costs 3,014 Euros [95% CI: 2.174-3.855]). Cost-effectiveness analyses favored MMM: QALY net gain 0.121 (95% CI 0.045-0.196); the cost-effectiveness ratio was 24,789 Euro/QALY.

conclusionsAlthough MMM was potentially cost-effective, the beneficial effects diminished over 3 years post-treatment. The findings highlight the need for strategies to sustain long-term effects.

Indexed as

Anxiety DisordersBehavioral SymptomsCognitive Behavioral TherapyCost-Benefit AnalysisCost-Effectiveness AnalysisDepressionOutcome Assessment, Health CareAdolescentChildFemaleFollow-Up StudiesHumansMalechildren and adolescentsCognitive behavioral therapymental health problemsschool‐based

Identifiers

PMID41774040
PMCPMC13341342

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.