Integrative analysis of quantitative trait loci of alternative polyadenylation and GWAS highlights key regulators of milk production and immune traits in Holstein.
Article in Animal genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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0cells of the map it votes in
1citing papers in PubMed
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1 · What the graph read from it
What it found
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2 · The registry
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5 · Who and what money
Authors and funding
7 authors.
Xinyue TaoState Key Laboratory of Animal Biotech Breeding, National Engineering Laboratory for Animal Breeding, Key Laboratory of Animal Genetics, Breedinge and Reproduction, Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology, China Agricultural University, Beijing, China.ORCID https://orcid.org/0009-0006-8185-1246
Yongjie TangState Key Laboratory of Animal Biotech Breeding, National Engineering Laboratory for Animal Breeding, Key Laboratory of Animal Genetics, Breedinge and Reproduction, Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology, China Agricultural University, Beijing, China.ORCID https://orcid.org/0000-0002-3298-9023
Xueqin LiuState Key Laboratory of Animal Biotech Breeding, National Engineering Laboratory for Animal Breeding, Key Laboratory of Animal Genetics, Breedinge and Reproduction, Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology, China Agricultural University, Beijing, China.ORCID https://orcid.org/0000-0002-8160-015X
Miaozhuo NiState Key Laboratory of Animal Biotech Breeding, National Engineering Laboratory for Animal Breeding, Key Laboratory of Animal Genetics, Breedinge and Reproduction, Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology, China Agricultural University, Beijing, China.ORCID https://orcid.org/0009-0002-5722-5182
Wanyi LaiState Key Laboratory of Animal Biotech Breeding, National Engineering Laboratory for Animal Breeding, Key Laboratory of Animal Genetics, Breedinge and Reproduction, Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology, China Agricultural University, Beijing, China.ORCID https://orcid.org/0009-0003-6868-0268
Siqian ChenState Key Laboratory of Animal Biotech Breeding, National Engineering Laboratory for Animal Breeding, Key Laboratory of Animal Genetics, Breedinge and Reproduction, Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology, China Agricultural University, Beijing, China.ORCID https://orcid.org/0009-0004-4737-7443
Ying YuState Key Laboratory of Animal Biotech Breeding, National Engineering Laboratory for Animal Breeding, Key Laboratory of Animal Genetics, Breedinge and Reproduction, Ministry of Agriculture and Rural Affairs, College of Animal Science and Technology, China Agricultural University, Beijing, China.ORCID https://orcid.org/0000-0002-4524-0791
Funding
National Key Research and Development Program of China 2021YFD1200903National Key Research and Development Program of China 2023YFF1000902National Natural Science Foundation of China - Pakistan Science Foundation Joint Research Project 31961143009the National Natural Science Foundation of China 32302706the National Natural Science Foundation of China 32472864the Program for Changjiang Scholar and Innovation Research Team in University IRT-15R62
6 · The paper itself
Abstract
Understanding the genetic regulation of complex traits like mastitis in Holstein dairy cows remains a challenge, despite significant advancements in breeding techniques. This study integrates 3'-untranslated region alternative polyadenylation (APA) quantitative trait loci (3'aQTL) mapping with genome-wide association studies (GWASs) to identify key genetic variants and regulatory genes influencing traits during early lactation. Heritability analysis showed that, on average, cis-acting SNPs explained 22% of percentage of distal polyA site usage index (PDUI) variance, supporting a genetic basis for APA regulation. Building on this, we identified 1143 significant cis-3'aQTL associated with PDUI variation across 215 genes (3'aGenes), with significant enrichment in immune system and disease-related pathways. Comparisons with expression quantitative trait loci (eQTL) revealed limited overlap, suggesting distinct regulatory mechanisms. SNP rs109421300 was found to co-localize with GWAS signals for milk protein, mastitis and ketosis traits. Further analysis linked rs109421300 to the regulation of GRINA via APA, with predicted transcription factor interactions involving NRF1 and RUNX. These findings enhance our understanding of the genetic basis of economically important traits in dairy cows and provide a foundation for precision breeding strategies.
Indexed as
LactationPolyadenylationQuantitative Trait Loci3' Untranslated RegionsAnimalsCattleFemaleGenome-Wide Association StudyMilkPolymorphism, Single Nucleotide3' Untranslated Regionsalternative polyadenylationcomplex traitsearly lactationHolsteinquantitative trait loci
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Integrative analysis of quantitative trait loci of alternative polyadenylation and GWAS highlights key regulators of milk production and immune traits in Holstein. · full record | OpenQuestion