Evidence map›Paper›PMID 41773934›Full record

Trial reportAntimicrobial agents and chemotherapy2026

Pharmacokinetics, safety, and tolerability of HRS-8427, a novel anti-carbapenem-resistant cephalosporin, in healthy subjects.

Tengrui Yin, Biao Qu, Qian Zhang, Sheng Xu, Yijue Wu, Hao Jiang, Yuanyuan Huang, Wei Hu

Abstract readRandomized Controlled TrialClinical Trial, Phase I
In one paragraph

Trial report in Antimicrobial agents and chemotherapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Tengrui Yin *Jiangsu Hengrui Medicine Co. Ltd., Lianyungang, People's Republic of China.ORCID 0009-0003-8423-505X
Biao Qu *Department of Clinical Pharmacology, The Second Affiliated Hospital of Anhui Medical University, Hefei, People's Republic of China.ORCID 0000-0001-8615-8666
Qian ZhangJiangsu Hengrui Medicine Co. Ltd., Lianyungang, People's Republic of China.
Sheng XuJiangsu Hengrui Medicine Co. Ltd., Lianyungang, People's Republic of China.
Yijue WuJiangsu Hengrui Medicine Co. Ltd., Lianyungang, People's Republic of China.
Hao JiangJiangsu Hengrui Medicine Co. Ltd., Lianyungang, People's Republic of China.
Yuanyuan HuangJiangsu Hengrui Medicine Co. Ltd., Lianyungang, People's Republic of China.ORCID 0009-0003-5851-4856
Wei HuDepartment of Clinical Pharmacology, The Second Affiliated Hospital of Anhui Medical University, Hefei, People's Republic of China.ORCID 0000-0002-4809-7601

Funding

National Natural Science Foundation Incubation Program of The Second Hospital of Anhui Medical University No.2022GMFY08
6 · The paper itself

Abstract

HRS-8427 is a novel parenteral siderophore cephalosporin that shows potent efficacy against various gram-negative bacteria, including carbapenem-resistant strains,

Indexed as

Anti-Bacterial AgentsCarbapenemsCephalosporinsAdultArea Under CurveFemaleHealthy VolunteersHumansMaleMicrobial Sensitivity TestsMiddle AgedYoung AdultAnti-Bacterial AgentsCarbapenemsCephalosporinscephalosporingram-negative bacteriaHRS-8427pharmacokineticssiderophores

Identifiers

PMID41773934
PMCPMC13041303

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.