Evidence map›Paper›PMID 41773868›Full record

ArticleMicrobiology spectrum2026

Limited contribution of compensatory mutations to MDR/RR-TB clustering in Hunan Province, China: a population-based whole-genome sequencing study.

Wencong He, Yunhong Tan, Zexuan Song, Hua Bai, Peilei Hu, Xichao Ou, Bing Zhao, Xiangyi Liu, Yanlin Zhao

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Microbiology spectrum, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Wencong HeDepartment of Clinical Laboratory, Capital Medical University, Beijing Tongren Hospital, Beijing, China.ORCID 0000-0002-0655-1706
Yunhong TanHunan Provincial Chest Hospital, Tuberculosis Control Institution of Hunan Province, Changsha, Hunan, China.
Zexuan SongDepartment of Clinical Laboratory, Capital Medical University, Capital Institute of Pediatrics, Beijing, China.
Hua BaiHunan Provincial Chest Hospital, Tuberculosis Control Institution of Hunan Province, Changsha, Hunan, China.
Peilei HuHunan Provincial Chest Hospital, Tuberculosis Control Institution of Hunan Province, Changsha, Hunan, China.
Xichao OuNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, Chinese Center for Disease Control and Prevention, National Center for Tuberculosis Control and Prevention, Beijing, China.
Bing ZhaoNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, Chinese Center for Disease Control and Prevention, National Center for Tuberculosis Control and Prevention, Beijing, China.
Xiangyi LiuDepartment of Clinical Laboratory, Capital Medical University, Beijing Tongren Hospital, Beijing, China.ORCID 0000-0003-0695-5353
Yanlin ZhaoNational Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, Chinese Center for Disease Control and Prevention, National Center for Tuberculosis Control and Prevention, Beijing, China.ORCID 0000-0002-7890-4312

Funding

Beijing Tongren Hospital (BTH), Capital Medical University 2023-YJJ-ZZL-026Chinese Center for Disease Control and Prevention 2428National Key R&D Program 2022YFC2305204, 2023YFC2307301
6 · The paper itself

Abstract

Transmission of rifampicin-resistant and multidrug-resistant tuberculosis (MDR/RR-TB) is a major driver of the global drug-resistant TB epidemic, yet the contribution of compensatory mutations to its spread remains uncertain. We analyzed 206 non-duplicate MDR/RR-TB isolates collected from five surveillance sites in Hunan Province, China, between 2013 and 2020 using whole-genome sequencing. Transmission clusters were defined by ≤12 single-nucleotide polymorphism (SNP) differences, and compensatory mutations in rpoA, rpoB, and rpoC were identified through a curated mutation catalog and phylogenetic evidence. Clusters were further classified based on whether compensatory mutations predated transmission (C-type), arose after transmission (M-type), or were absent (N-type), with M-type clusters excluded to reduce confounding. Among the 206 isolates, 63 (30.6%) carried at least one compensatory mutation, predominantly in rpoC, and 27 clusters (32.5%) were identified, ranging from 2 to 6 isolates. No significant difference was observed in clustering frequency between compensated and non-compensated strains (21.7% vs 32.8%,

Indexed as

Drug Resistance, Multiple, BacterialMutationMycobacterium tuberculosisTuberculosis, Multidrug-ResistantAntitubercular AgentsBacterial ProteinsChinaGenome, BacterialHumansPhylogenyPolymorphism, Single NucleotideRifampinWhole Genome SequencingAntitubercular AgentsBacterial ProteinsRifampincompensatory mutationsMDR/RR-TBtransmissiontuberculosiswhole-genome sequencing

Identifiers

PMID41773868
PMCPMC13055236

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.