Evidence map›Paper›PMID 41773865›Full record

ArticlemBio2026

ATP1A1 enhances porcine reproductive and respiratory syndrome virus type 2 attachment and internalization.

Haotian Yang, Bicheng Li, Xudong Yin, Aldryan Cristianto Pratama, Fang He

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mBio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Haotian Yang *MOA Key Laboratory of Animal Virology, Zhejiang University Center for Veterinary Sciences, Hangzhou, China.
Bicheng Li *MOA Key Laboratory of Animal Virology, Zhejiang University Center for Veterinary Sciences, Hangzhou, China.
Xudong YinMOA Key Laboratory of Animal Virology, Zhejiang University Center for Veterinary Sciences, Hangzhou, China.
Aldryan Cristianto PratamaMOA Key Laboratory of Animal Virology, Zhejiang University Center for Veterinary Sciences, Hangzhou, China.
Fang HeMOA Key Laboratory of Animal Virology, Zhejiang University Center for Veterinary Sciences, Hangzhou, China.ORCID 0000-0002-9106-1938

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Na IMPORTANCE: PRRSV continues to cause severe financial losses to the global swine industry. It is feasible to develop safe and effective antiviral strategies based on the initial step of viral infection, that is, the recognition of the virus by the cellular entry factors. However, the interactions between PRRSV and host factors initiating viral attachment and internalization are not fully understood yet. In this study, ATP1A1 was identified to promote both PRRSV-2 attachment and internalization through macropinocytosis and caveolae/raft-dependent endocytosis. These findings reveal an unrecognized entry mechanism of PRRSV-2 and provide novel insights for the development of antiviral drugs and vaccines against the virus.

Indexed as

Porcine Reproductive and Respiratory SyndromePorcine respiratory and reproductive syndrome virusSodium-Potassium-Exchanging ATPaseVirus AttachmentVirus InternalizationAnimalsCell LineEndocytosisSwineSodium-Potassium-Exchanging ATPaseATP1A1endocytotic pathwayPRRSVvirus blocking strategyvirus entry

Identifiers

PMID41773865
PMCPMC13059770

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.