ArticleCritical care explorations2026
Feasibility of Calculating and Maintaining Near-Infrared Spectroscopy-Guided Personalized Mean Arterial Pressure Targets in Adults With Critical Illness: A Pilot Clinical Study.
Article in Critical care explorations, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesCritically ill patients have a high risk for delirium, which may result from inadequate cerebral perfusion. One resuscitation goal for adult critically ill patients is maintaining mean arterial pressure (MAP) greater than 65 mm Hg, regardless of diagnosis or patient characteristics. Recent data suggest a high degree of individual variability in optimal MAP (MAPopt) due, in part, to whether autoregulation is intact or absent. The overall objective of this study was to evaluate the feasibility of maintaining critically ill patients within an individualized MAPopt range identified noninvasively with near-infrared spectroscopy, a technology that measures regional cerebral oxygen saturation (rSo2).
designPilot interventional feasibility study.
settingMixed ICU at a tertiary hospital. PATIENTS: Sixteen adult critically ill patients were enrolled within 24 hours of ICU admission. Exclusion criteria included expected survival less than 24 hours, neurologic or neurosurgical diagnoses, absence of an arterial catheter, or pregnancy.
interventionsMAP and rSo2 data were recorded for 24 hours and processed through a custom algorithm. A running correlation coefficient between MAP and rSo2 was generated. Periods where there was zero or negative correlation between MAP and rSo2 reflected intact autoregulation. The MAP range where this correlation was near zero was determined to be the MAPopt. Vasoactive medications were used to maintain patients within that target range for the next 48 hours. MEASUREMENTS AND MAIN
resultsThe enrollment rate was 0.5 patients/mo (goal 1/mo). MAPopt was successfully identified in 12 patients (75%) and maintained for 61% ± 17% of the follow-up period. The proportion of time spent within MAPopt strongly correlated with the width of the MAPopt range (r = 0.729; p = 0.017). There were no adverse events associated with the intervention.
conclusionsAlthough enrollment was lower than expected, MAPopt was calculated in the majority of patients. Maintaining patients within individualized MAPopt ranges was challenging, particularly when this range was narrow.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.