Evidence map›Paper›PMID 41773735›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

TRAP5 Inhibition Targeting Scar-Associated Macrophages Ameliorates Acute Kidney Injury to Chronic Kidney Disease Transition.

Chenxi Wang, Yaodong Gu, Wen Du, Lin Xie, Jinwei Quan, Yu Zhao, Ye Cheng, Zhaonan Wei, Yuanyuan Sha, Yi Wang and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Chenxi WangDepartment of Nephrology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Yaodong GuDepartment of Nephrology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Wen DuDepartment of Nephrology, Ruijin Hospital Luwan Branch, Shanghai Jiaotong University School of Medicine, Shanghai, China.
Lin XieDepartment of Nephrology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Jinwei QuanDepartment of Nephrology, Shanghai Fourth People's Hospital, Tongji University, Shanghai, China.
Yu ZhaoDepartment of Nephrology, Ningbo Yinzhou No.2 Hospital, Ningbo, China.
Ye ChengDepartment of Nephrology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Zhaonan WeiDepartment of Nephrology, The Second Affiliated Hospital of Soochow University, Suzhou, China.
Yuanyuan ShaDepartment of Intensive Care Unit, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Yi WangDepartment of Nephrology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Dechao XuDepartment of Nephrology, Changzheng Hospital, Naval Medical University, Shanghai, China.
Xiang GaoDepartment of Nephrology, Shanghai Fourth People's Hospital, Tongji University, Shanghai, China.
Min ChenDepartment of Nephrology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Xiangchen GuDepartment of Nephrology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.ORCID https://orcid.org/0000-0003-1159-8565

Funding

National Natural Science Foundation of China 82474175Research Startup Funding of Shanghai Fourth People's Hospital Affiliated to Tongji University sykyqd11801Science and Technology Innovation Action Plan of Shanghai Science and Technology Commission 23S11900500Shanghai Sailing Program, Shanghai Rising-Star Project 24YF2727000Youth Fund of National Natural Science Foundation of China 82500855
6 · The paper itself

Abstract

The transition from acute kidney injury (AKI) to chronic kidney disease (CKD) lacks effective therapies. Using a murine aristolochic acid I model (AAI), followed by a 2 week remodeling phase, we mapped macrophage states across the AKI to CKD transition. Single-cell RNA sequencing of kidneys from control, acute, and remodeling stages profiled 39 345 cells spanning 18 clusters. Macrophage subclustering and trajectories revealed emergence of scar-associated macrophages (SMs) marked by high Acp5 (encoding tartrate-resistant acid phosphatase 5 (TRAP5)) and enriched during the remodeling phase. Cell-cell communication highlighted a dominant Spp1-Cd44 axis driving SM activation. Immunofluorescence confirmed TRAP5

Indexed as

Acute Kidney InjuryCicatrixMacrophagesRenal Insufficiency, ChronicTartrate-Resistant Acid PhosphataseAnimalsAristolochic AcidsDisease Models, AnimalDisease ProgressionHumansMaleMiceMice, Inbred C57BLOsteopontinaristolochic acid IAristolochic AcidsOsteopontinTartrate-Resistant Acid PhosphataseACP5/TRAP5AKI to CKD transitionAristolochic Acid IMacrophagesingle‐cell RNA sequencing

Identifiers

PMID41773735
PMCPMC13159109

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.