ArticleThoracic research and practice2026
CT-defined Emphysema Morphology as a Predictor for Histological Subtypes of Lung Cancer: A Single-center Retrospective Study.
Article in Thoracic research and practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Response to: Letter to the Editor Regarding CT-based Prediction of Lung Cancer Histology.Thoracic research and practice · 2026Article
- Comment on: Letter to the Editor Regarding CT-based Prediction of Lung Cancer Histology.Thoracic research and practice · 2026Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveLung cancer and pulmonary emphysema share common risk factors and pathophysiological pathways. Emerging evidence suggests that emphysema morphology, rather than emphysema burden, may influence lung cancer histology. This study evaluated the association between computed tomography (CT)-defined emphysema characteristics and histological subtypes of lung cancer. MATERIAL AND
methodsA retrospective observational cohort study was conducted that included 144 patients with histologically confirmed lung cancer who underwent diagnostic thoracic CT between January 2020 and June 2024 at Dr. Saiful Anwar General Hospital in Indonesia. Emphysema morphology was visually classified as centrilobular emphysema (CLE), paraseptal emphysema, or mixed, and emphysema volume was quantified using 3D Slicer software. Associations with histological subtypes were analyzed using bivariate analyses and multivariate logistic regression, adjusted for age, sex, tumor size, and tumor location. Model performance was assessed using receiver operating characteristic analysis.
resultsAdenocarcinoma (ADC) was the most common subtype (65.3%). Emphysema was present in 37.5% of patients and occurred more frequently in non-ADC subtypes. Emphysema morphology was significantly associated with histological subtype (
conclusionCT-defined CLE is independently associated with lung ADC, whereas emphysema volume is not predictive of lung ADC. Emphysema morphology may serve as a non-invasive imaging biomarker to support histological risk stratification when tissue diagnosis is limited.
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