Evidence map›Paper›PMID 41773461›Full record

ArticleACS applied bio materials2026

Engineering a Bioactive PMMA-Silica Hybrid Scaffold for Enhanced Bone Regeneration.

Susaritha Ramanathan, Yu-Chien Lin, Huey-Yuan Wang, Ching-Li Tseng, Siwei Li, Wai-Ching Liu, Udesh Dhawan, Chih-Chien Hu, Ren-Jei Chung

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In one paragraph

Article in ACS applied bio materials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Susaritha RamanathanDepartment of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei 10608, Taiwan.
Yu-Chien LinSchool of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore.ORCID 0000-0003-3290-439X
Huey-Yuan WangDepartment of Stomatology, MacKay Memorial Hospital, Taipei 104217, Taiwan.
Ching-Li TsengGraduate Institute of Biomedical Materials and Tissue Engineering, College of Biomedical Engineering, Taipei Medical University, Taipei 11031, Taiwan.ORCID 0000-0001-9446-4030
Siwei LiVSSAcademy Training & Education Ltd Office 6.072 sixth Floor, First Central 200, 2 Lakeside Drive, London NW10 7FQ, U.K.ORCID 0000-0002-1042-0012
Wai-Ching LiuDepartment of Food and Health Sciences, Technological and Higher Education Institute of Hong Kong, New Territories, Hong Kong 999077, China.
Udesh DhawanCentre for the Cellular Microenvironment, Division of Biomedical Engineering, James Watt School of Engineering, Mazumdar-Shaw Advanced Research Centre, University of Glasgow, Glasgow G116EW, U.K.
Chih-Chien HuBone and Joint Research Center, Chang Gung Memorial Hospital, Kweishan, Taoyuan 33305, Taiwan.
Ren-Jei ChungDepartment of Chemical Engineering and Biotechnology, National Taipei University of Technology, Taipei 10608, Taiwan.ORCID 0000-0002-0655-3680

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bone health is crucial for maintaining mobility, structural integrity, and overall well-being. However, bone-related surgeries are the second most common type of tissue transplant worldwide. A reliable and bioactive material is needed to address these issues. This has led to growing interest in bone tissue engineering (BTE) as a viable substitute strategy. Poly(methyl methacrylate) (PMMA) is a commonly utilized material in implant fixation and bone tissue applications due to its mechanical and chemical stability and ease of processing. However, its low bioactivity and poor osseointegration limit its effectiveness in bone repair, posing a significant technical challenge. In this study, we developed a PMMA-silica hybrid scaffold using tetraethyl orthosilicate (TEOS) as a silica source and 3-glycidoxypropyltrimethoxysilane (GPTMS) as a coupling agent. By incorporating silica, we aimed to enhance the bioactivity of PMMA, improve cell adhesion, and foster better integration with bone tissue. The effectiveness of the scaffold was assessed through

Indexed as

Biocompatible MaterialsBone RegenerationPolymethyl MethacrylateSilicon DioxideTissue EngineeringTissue ScaffoldsAnimalsCell AdhesionCell ProliferationMaterials TestingParticle SizeRatsRats, Sprague-DawleySurface PropertiesBiocompatible MaterialsPolymethyl MethacrylateSilicon Dioxidebiocompatibilitybone regenerationhybrid materialsosseointegrationpoly(methyl methacrylate) (PMMA)

Identifiers

PMID41773461
PMCPMC12997158

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.