ReviewClinical ophthalmology (Auckland, N.Z.)2026
Efficacy and Safety of Ab-externo Approach versus Ab-interno Approach of XEN45 Gel Stent Implantation: A Systematic Review and Meta-Analysis.
Review in Clinical ophthalmology (Auckland, N.Z.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Comparative efficacy and safety of ab-interno XEN 45 gel implantation versus trabeculectomy for glaucoma: a systematic review and meta-analysis.Therapeutic advances in ophthalmologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: The XEN45 Gel Stent is a microinvasive glaucoma surgery (MIGS) device designed to lower intraocular pressure (IOP) by enhancing aqueous humor outflow. This systematic review and meta-analysis aimed to compare efficacy and safety of the Methods: A comprehensive literature search was conducted using PubMed, Web of Science, the Cochrane Library, the Registry of Controlled Trials, and the Directory of Open Access Journals. Of 216 screened articles, six retrospective studies met inclusion criteria. Primary outcomes included reduction in mean baseline IOP and number of IOP-lowering medications required postoperatively. Statistical analysis was performed using Stata (StataCorp, 2025). Results: A total of 614 eyes were analyzed. Three hundred and eighteen treated with the Conclusion: Both
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.