ArticlePsychological medicine2026
Inefficient integration between effort and reward in anhedonia.
Article in Psychological medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundAnhedonia is defined as a reduced interest in or inability to experience pleasure from reward-related activities. Recent studies have demonstrated deficient effort-based motivation in anhedonia, but the neural dynamics underlying the interface between effort and reward remain unclear.
methodsTo address this issue, we recruited an anhedonia (ANH) group (
resultsAs expected, the ANH group showed reduced reward responses in both self-reported ratings and event-related potential (ERP) data in response to cue stimuli (indexed by the cue-P3) and reward feedback (indexed by the reward positivity). Importantly, the ANH group exhibited inefficient integration between effort and reward, showing an absent effort-discounting effect on the feedback-P3 during reward evaluation and a lack of reward-related theta modulation during effort-based decision-making.
conclusionsOur findings suggest a neurodynamic motivation model in anhedonia that informs precise interventions for relevant neuropsychiatric disorders.
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