Evidence map›Paper›PMID 41773037›Full record

ArticleHistology and histopathology2026

Application of the ultrasonic oscillation flotation method in paraffin section preparation.

Min Zhang, Yue Chen, Lü Ren, Jinzhi Xia, Lu Tao, Jianguo Hu, Jing Li, Xiaofeng Zhang, Zhijun Geng, Yueyue Wang and 1 more

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Article in Histology and histopathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Min Zhang *Department of Clinical Laboratory, First Affiliated Hospital of Bengbu Medical University, Bengbu, China.
Yue Chen *School of Laboratory Medicine, Bengbu Medical University, Bengbu, China.
Lü RenSchool of Laboratory Medicine, Bengbu Medical University, Bengbu, China.
Jinzhi XiaDepartment of Clinical Laboratory, First Affiliated Hospital of Bengbu Medical University, Bengbu, China.
Lu TaoAnhui Province Key Laboratory of Basic and Translational Research of Inflammation-Related Diseases, First Affiliated Hospital of Bengbu Medical University, Bengbu, China.
Jianguo HuDepartment of Clinical Laboratory, First Affiliated Hospital of Bengbu Medical University, Bengbu, China.
Jing LiDepartment of Clinical Laboratory, First Affiliated Hospital of Bengbu Medical University, Bengbu, China.
Xiaofeng ZhangAnhui Province Key Laboratory of Basic and Translational Research of Inflammation-Related Diseases, First Affiliated Hospital of Bengbu Medical University, Bengbu, China.
Zhijun GengAnhui Province Key Laboratory of Basic and Translational Research of Inflammation-Related Diseases, First Affiliated Hospital of Bengbu Medical University, Bengbu, China.
Yueyue WangAnhui Province Key Laboratory of Basic and Translational Research of Inflammation-Related Diseases, First Affiliated Hospital of Bengbu Medical University, Bengbu, China.
Xue SongDepartment of Central Laboratory, First Affiliated Hospital of Bengbu Medical University, Bengbu, China.

Funding

Graduate Research Innovation Program of Bengbu Medical College Byycx23065Key Research Project of Natural Science in Universities of Anhui Province 2023AH040289National Natural Science Foundation of China 82370534Natural Science Foundation of Bengbu Medical College 2020bypd010
6 · The paper itself

Abstract

objectiveTo enhance the quality and efficiency of paraffin-embedded pathological section preparation, this study aims to investigate the potential benefits of utilizing the ultrasound oscillation flotation method (UOFM) for section spreading.

methodsSpecimens of various tissue types were processed using both the conventional and UOFM for section spreading. The presence of wrinkles or damage during this process was assessed through HE staining, with the number of wrinkles being quantified. The optimal frequency and power density for section spreading were determined by evaluating the qualified rate of sections at various frequencies and power densities, and the average time required for section spreading was compared between the two methods.

resultsThe results showed that pathological sections of various tissue types rarely showed paraffin dissolution and section breaking after the UOFM. HE staining also revealed that the group exhibited significantly reduced wrinkling and a more intact tissue structure compared with the conventional method group (

conclusionsThe UOFM effectively maintains the structural integrity of paraffin pathological sections, significantly enhancing the quality of sections and optimizing section preparation efficiency.

Indexed as

Paraffin EmbeddingUltrasonic WavesAnimalsHumans

Identifiers

PMID41773037

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