Observational studyAnnals of the American Thoracic Society2026
The PRECIsE study: a prospective, multicenter study of shape-sensing robotic-assisted bronchoscopy with 2 years of follow-up.
Observational study in Annals of the American Thoracic Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Device-procedure attribution of reported harm in robotic-assisted bronchoscopy: a MAUDE study informing safety surveillance of robotic surgical systems.Journal of robotic surgery · 2026Article
- Sensitivity for Malignancy with Navigation Bronchoscopy in Small Lung Nodules.Advances in respiratory medicine · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
rationaleGuidelines recommend nonsurgical biopsy for indeterminate pulmonary lesions >8 mm. Shape-sensing robotic-assisted bronchoscopy (ssRAB) is growing in use to biopsy small pulmonary nodules; however, current literature is limited to single-center studies with limited follow-up.
objectivesThis study, PRECIsE, assessed safety and performance of the first ssRAB iteration across multiple sites and nascent users.
methodsThis was a prospective, multicenter, observational study evaluating ssRAB without cone-beam computed tomography guidance in patients with nodules 10 to 30 mm located in or beyond the sub-segmental airways. Patients were followed for 2 years; the primary endpoint was sensitivity for malignancy with diagnostic yield, and safety as secondary endpoints. Multilevel logistic regression models were used to control for factors associated with sensitivity and diagnostic yield.
resultsA total of 305 procedures were performed across 6 centers. Median nodule size was 17.0 mm (IQR, 14.0-23.0) with bronchus sign present in 37% of cases. Sensitivity for malignancy through 2 years was 81.3% (95% CI, 75.7%-86.1%). Multilevel modeling demonstrated that female sex, smaller nodule size, lower lobe location, semi-solid density, and higher body mass index were associated with lower sensitivity. Diagnostic yield was 74.1% (95% CI, 68.8%-78.9%) according to the American Thoracic Society/American College of Chest Physicians (ATS/ACCP) criteria and 77.5% (95% CI, 72.4%-81.8%) according to the intermediate criteria. Multilevel modeling demonstrated a nonsignificant site/center-level effect on ATS/ACCP diagnostic yield (P = .36). Pneumothorax requiring intervention was 1.6% (5/305); bleeding was 1.0% (3/305) with 2 Nashville grade 2 events and one Nashville grade 3 event.
conclusionsThe first iteration of ssRAB demonstrated encouraging performance and a strong safety profile among nascent users for the biopsy of small peripheral nodules.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.