ArticleVeterinary medicine and science2026
Oral Acute Toxicity and Genotoxicity of Heteroctenus junceus Scorpion Venom.
Article in Veterinary medicine and science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
objectiveThe study evaluates the elemental composition, oral acute toxicity, genotoxicity, and mutagenic potential of Heteroctenus junceus scorpion venom.
methodsThe elemental composition was determined by atomic absorption spectrophotometry and HPLC-MS/MS. The acute oral toxicity test was assessed in mice at 300 and 2000 mg/kg. The in vivo micronucleus test was conducted in mice treated with three scorpion venom doses (10, 100, and 1000 mg/kg). Meanwhile, the in vitro micronucleus test was conducted in TK6 cells treated with three scorpion venom doses (1.25, 2.5, and 5 mg/mL). The Ames test followed the OECD guidelines, and various scorpion venom concentrations (0.16, 0.32, 0.63, 1.25, 2.5, 5 mg/mL) were used.
resultsThe elemental analysis of scorpion venom reveals the lowest amino acid and elemental composition levels compared to other species. An LD
conclusionsH. junceus venom has a low toxicological potential.
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