Evidence map›Paper›PMID 41772819›Full record

ArticleJournal of viral hepatitis2026

Prevalence of Active HCV Infection in Spain in 2022 Using Multiparameter Evidence Synthesis.

Christos Thomadakis, Ilias Gountas, Konstantinos Gountas, Nestor Nuño, Begoña Brime, Rosario Sendino, Agustín Albillos, María Buti, Javier Crespo, Juan Berenguer and 18 more

Abstract read
In one paragraph

Article in Journal of viral hepatitis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

28 authors.

Christos ThomadakisMedical School, University of Cyprus, Nicosia, Cyprus.ORCID https://orcid.org/0000-0001-9560-1121
Ilias GountasMedical School, University of Cyprus, Nicosia, Cyprus.
Konstantinos GountasMedical School, University of Cyprus, Nicosia, Cyprus.
Nestor NuñoTRAGSATEC, Madrid, Spain.
Begoña BrimeSpanish National Plan on Drugs, Ministry of Health, Madrid, Spain.
Rosario SendinoSpanish National Plan on Drugs, Ministry of Health, Madrid, Spain.
Agustín AlbillosRamón y Cajal University Hospital, Madrid, IRYCIS, Universidad de Alcalá, Madrid, Spain.ORCID https://orcid.org/0000-0001-9131-2592
María ButiCenter for Biomedical Research in Hepatology Diseases (CIBEREHD), Institute of Health Carlos III, Madrid, Spain.
Javier CrespoCenter for Biomedical Research in Hepatology Diseases (CIBEREHD), Institute of Health Carlos III, Madrid, Spain.
Juan BerenguerGregorio Marañón University Hospital (IiSGM), Madrid, Spain.
Sonia AlonsoGregorio Marañón University Hospital (IiSGM), Madrid, Spain.
Alberto Díaz de SantiagoPuerta de Hierro University Hospital, Majadahonda, Spain.
Victoria HernandoCenter for Biomedical Research in Infectious Diseases Network (CIBERINFEC), Institute of Health Carlos III, Madrid, Spain.
Montserrat LagunoCenter for Biomedical Research in Infectious Diseases Network (CIBERINFEC), Institute of Health Carlos III, Madrid, Spain.ORCID https://orcid.org/0000-0002-7798-6352
Sabela LensCenter for Biomedical Research in Hepatology Diseases (CIBEREHD), Institute of Health Carlos III, Madrid, Spain.
Moisés DiagoGeneral University Hospital, Valencia, Spain.
Maria Luisa MontesCenter for Biomedical Research in Infectious Diseases Network (CIBERINFEC), Institute of Health Carlos III, Madrid, Spain.
Javier García-SamaniegoCenter for Biomedical Research in Hepatology Diseases (CIBEREHD), Institute of Health Carlos III, Madrid, Spain.
Luis MoranoÁlvaro Cunqueiro University Hospital, Vigo, Spain.
Juan Luis MorenoGeneral Subdirectorate of Pharmacy and Health Products, Ministry of Health, Madrid, Spain.
Jordi NavarroVall D'Hebron Hospital Universitari, Barcelona, Spain.
Manuel Romero-GómezCenter for Biomedical Research in Hepatology Diseases (CIBEREHD), Institute of Health Carlos III, Madrid, Spain.ORCID https://orcid.org/0000-0001-8494-8947
Laura SantosGeneral Subdirectorate of Pharmacy and Health Products, Ministry of Health, Madrid, Spain.
Raúl SorianoExternal Consultant, Valencia, Spain.
Erika DuffellEuropean Centre for Disease Prevention and Control, Stockholm, Sweden.
Asuncion DiazCenter for Biomedical Research in Infectious Diseases Network (CIBERINFEC), Institute of Health Carlos III, Madrid, Spain.
Julia Del AmoDivision for HIV, STI, Viral Hepatitis and Tuberculosis Control, Ministry of Health, Madrid, Spain.
Georgios NikolopoulosMedical School, University of Cyprus, Nicosia, Cyprus.

Funding

Ministry of Health, Spain
6 · The paper itself

Abstract

Hepatitis C virus (HCV) remains a major public health concern worldwide. Spain has implemented large-scale direct-acting antiviral (DAA) treatment programs, yet the prevalence of active HCV infection (aHCV) and its trends over time remain incompletely characterised. We applied Bayesian multiparameter evidence synthesis (MPES) to estimate the prevalence of aHCV in Spain in 2022 and its change from 2019 to 2022. The Spanish population aged 15-79 years was stratified into four non-overlapping risk groups: current people who inject drugs (PWID), ex-PWID, gay-bisexual and other men who have sex with men (GBMSM) engaging in chemsex (GBMSMchem), and the general population. Data sources included, among others, national seroprevalence surveys, behavioural studies, national databases, and clinical records on DAA treatment outcomes. The estimated overall aHCV prevalence in Spain in 2022 was 0.14% (95% Credible Interval: 0.05%-0.27%), corresponding to approximately 54,500 individuals. Prevalence was highest among current PWID (12.5%) and GBMSMchem (8.4%). Compared to 2019, the total number of aHCV cases declined by ~20,000, largely attributable to DAA treatment. Among the general population, 29.4% of aHCV cases remained undiagnosed, with the highest prevalence in individuals aged 50-59 (0.25%) and 60-69 (0.16%) years. Spain has made substantial progress towards HCV elimination, but key populations such as PWID and GBMSMchem remain at high risk. Targeted interventions, including expanded harm reduction services and accessible HCV testing and treatment, are essential to achieving the World Health Organization (WHO) elimination targets by 2030.

Indexed as

Hepatitis CAdolescentAdultAgedAntiviral AgentsBayes TheoremHepacivirusHumansMaleMiddle AgedPrevalenceSpainSubstance Abuse, IntravenousYoung AdultAntiviral Agentsactive HCV infectionBayesian evidence synthesiskey populationspopulation prevalenceSpain

Identifiers

PMID41772819
PMCPMC12954168

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.