ArticleTransfusion2026
Microcirculatory perfusion is improved with plasma, but not with crystalloids, in a rat polytraumatic shock model.
Article in Transfusion, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTraumatic shock is associated with microcirculatory dysfunction. Plasma resuscitation for traumatic shock outside the context of bleeding may exert benefit by augmenting intravascular volume and inhibiting endotheliopathy. However, its effects on microcirculatory perfusion and tissue oxygenation in trauma remain poorly understood. STUDY DESIGN AND
methodsFollowing polytraumatic injury and shock induction with controlled bleeding, rats (n = 11) received crystalloids or plasma until mean arterial pressure (MAP) was 65 mmHg for 2 h, after resuscitation was stopped. Total vessel density (TVD), functional capillary density (FCD), proportion of perfused vessel density (PPV), and tissue red blood cell perfusion (tRBCp) were evaluated. Microcirculatory oxygen availability (μHbO
resultsAfter resuscitation, MAP was restored in both groups. However, TVD, FCD, and tRBCp were impaired in the crystalloid group as compared to the sham (p < 0.05), which did not occur in the plasma group. tRBCp was significantly improved by plasma resuscitation compared to crystalloid (p < 0.05). After resuscitation had stopped, TVD, FCD, and tRBCp remained significantly higher in the plasma group compared to the crystalloid group (p < 0.05). sVCAM decreased significantly by plasma compared to crystalloid (p < 0.05). There was no significant change in hyaluronan and μHbO
conclusionsPlasma, but not crystalloids, preserved microcirculatory diffusion and perfusion, which was associated with correction of endothelial functionality in rats requiring fluids following traumatic shock. Results suggest that plasma may be used in traumatic shock patients with persistent need of volume after bleeding has been contained.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.