ArticleRespiratory research2026
The identification of RNA splicing aberrations and their potential regulatory network in Chinese non-small cell lung cancer.
Article in Respiratory research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundAlternative splicing contributes to the carcinogenic process of non-small cell lung cancer. Although extensive efforts have characterized cancer-associated alternative splicing events, the upstream regulators governing these aberrant splicing events remain poorly understood.
methodsHere, we integrated multi-omics data from 22 lung adenocarcinoma, 13 lung squamous cell carcinoma and matched adjacent normal tissues of Chinese patients. We aimed to identify cancer-associated splicing events, construct regulatory networks of RBP, miRNA and DNA methylation on them and dissect carcinogenic pathways at integrated multi-omics layers in lung adenocarcinoma and squamous cell carcinoma, respectively.
resultsWe identified that immune-suppression pathways and oxidative phosphorylation specifically promote the progression of adenocarcinoma and squamous cell carcinoma, respectively. ATP5F1C exon 9 inclusion in adenocarcinoma and LTBP3 exon 25 exclusion in squamous cell carcinoma, involved in proliferation, invasion and metastasis, are key splicing events with therapeutic potential. Furthermore, we proposed miR-4521-PABPC5-ATP5F1C, miR-4423-3p-IGF2BP3/miR-944-RBMS3-LTBP3 as upstream regulatory axes potentially driving these events. Notably, genome-wide CpG methylation exhibited widespread association with distant splicing events, potentially playing a trans-regulatory role by disrupting splice factor (BCL11B, RUNX1, RUNX2) binding near CpG sites and inhibiting RBMS3 transcription.
conclusionsOur findings shed light on the potential functional impact and multi-layer regulation of cancer-associated splicing events, offering novel insights for splicing-switching therapies to improve non-small cell lung cancer treatment and prognosis.
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