ArticleMuscle & nerve2026
Demyelinating Leprosy Neuropathy: An Unusual and Misleading Electrophysiological Pattern.
Article in Muscle & nerve, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
INTRODUCTION/
aimsPeripheral neuropathy, especially mononeuropathy multiplex, is a frequent manifestation of leprosy. Electrodiagnostic studies (EDX) usually show predominant axonal involvement. In this study, we report patients with prominent demyelinating abnormalities consistent with the diagnosis of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP).
methodsWe retrospectively reviewed the medical records of patients with leprosy who underwent EDX at Pitié-Salpêtrière University Hospital, Paris, France, between January 2014 and June 2022. We included patients exhibiting demyelinating abnormalities that fulfilled the 2021 European Academy of Neurology/Peripheral Nerve Society (EAN/PNS) electrodiagnostic criteria for CIDP.
resultsTen patients were included. Eight patients presented with conduction blocks (CB) and temporal dispersion (TD) outside entrapment sites, primarily localized on the median and ulnar nerves in the forearm. Eight patients demonstrated delayed or absent F-waves in nerves without segmental slowing or CB/TD. Two patients were initially diagnosed with multifocal CIDP and treated accordingly before a nerve biopsy corrected the diagnosis. Follow-up EDX after anti-leprosy treatment revealed partial improvement or complete resolution of CB/TD in six patients, with improvement in distal motor amplitudes in four patients. DISCUSSION: Patients with leprosy neuropathy can exhibit demyelinating abnormalities on EDX, particularly CB/TD in the forearm, which may misleadingly suggest an immune-mediated origin, such as multifocal CIDP. In patients from leprosy-endemic areas with a demyelinating neuropathy fulfilling electrodiagnostic criteria for CIDP, clinicians should perform a dermatological examination, repeat bacteriological and histological sampling, and consider performing a nerve biopsy if diagnostic doubt persists.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.