Evidence map›Paper›PMID 41772383›Full record

ArticleJournal of cellular and molecular medicine2026

Immune Microenvironment Dynamics and Therapeutic Targets in GIST Revealed by Multi-Omics and Functional Validation.

Xingyuan Li, Jun Xiang, Zewen Chang, Qingchao Tang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular and molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Xingyuan LiDepartment of Colorectal Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Jun XiangDepartment of Colorectal Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Zewen ChangDepartment of General Surgery, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China.
Qingchao TangDepartment of Colorectal Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.ORCID https://orcid.org/0009-0008-6917-7003

Funding

Noncommunicable Chronic Diseases-National Science and Technology Major Project 2024ZD0520100.
6 · The paper itself

Abstract

The tumour immune microenvironment (TIME) significantly influences the progression and treatment response of gastrointestinal stromal tumours (GIST), but the causal mechanisms and therapeutic targets remain incompletely understood. We integrated multi-omics analyses, including Mendelian randomization analysis of 731 immune cell phenotypes to assess their causal relationship with GIST, mediation analysis to identify plasma metabolite mediators, single-cell RNA sequencing (scRNA-seq) to characterise TIME heterogeneity and bulk RNA-seq to screen for differentially expressed genes. Using the GIST-882 cell and CD8

Indexed as

Gastrointestinal NeoplasmsGastrointestinal Stromal TumorsTumor MicroenvironmentCD8-Positive T-LymphocytesCell Line, TumorGene Expression Regulation, NeoplasticHumansMultiomicsgastrointestinal stromal tumourimmune cellsimmune microenvironmentmendelian randomizationrisk factors

Identifiers

PMID41772383
PMCPMC12953045

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.