Evidence map›Paper›PMID 41772326›Full record

ArticleArchives of women's mental health2026

Attention-deficit/hyperactivity disorder medication use and cardiometabolic conditions in pregnancy: a population-based cohort study.

Andrea Sit, Claudia Bruno, Masako Araki, Malcolm B Gillies, Helga Zoega

Abstract read
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Article in Archives of women's mental health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Andrea SitSchool of Population Health, Faculty of Medicine and Health, UNSW Sydney, Sydney, Australia.ORCID 0000-0003-3551-4004
Claudia BrunoSchool of Population Health, Faculty of Medicine and Health, UNSW Sydney, Sydney, Australia.ORCID 0000-0001-7789-3415
Masako ArakiSchool of Population Health, Faculty of Medicine and Health, UNSW Sydney, Sydney, Australia.
Malcolm B GilliesSchool of Population Health, Faculty of Medicine and Health, UNSW Sydney, Sydney, Australia.ORCID 0000-0001-9038-8050
Helga ZoegaCentre of Public Health Sciences, Faculty of Medicine, University of Iceland, Reykjavik, Iceland. helgaz@hi.is.ORCID 0000-0003-0761-9028

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeUse of medications to treat attention-deficit/hyperactivity disorder (ADHD) is increasingly prevalent among women of reproductive age, but little is understood about their potential cardiometabolic effects in pregnancy. We aimed to examine associations between ADHD medication use and cardiometabolic conditions during pregnancy (gestational hypertension, preeclampsia, and gestational diabetes) and the pharmacological treatment thereof.

methodsLinking statewide hospital and dispensing data, we conducted a population-based matched cohort study of women who gave birth between January 2014 and June 2021 in New South Wales, Australia (n = 312,697). We compared the incidence of cardiometabolic conditions and cardiometabolic medication use during pregnancy among women who used ADHD medications during pregnancy (n = 336) with a 1:10 matched cohort of unexposed women, and with women who used ADHD medications in the 12 months before pregnancy (n = 252). We used Poisson regression models to calculate risk ratios (RR) and 95% confidence intervals (CI), adjusting for sociodemographic and pregnancy-related factors.

resultsCompared with unexposed women, women who used ADHD medications during pregnancy had an increased risk of gestational hypertension (adjusted RR: 1.76, 95% CI: 1.20-2.57) and gestational diabetes (aRR: 1.41, 95% CI: 1.09-1.82), with slightly elevated risk estimates for preeclampsia (aRR: 1.30, 95% CI: 0.82-2.05) and cardiometabolic medication use (aRR: 1.40, 95% CI: 0.97-2.01). Compared with women who used ADHD medications before pregnancy only, risk estimates attenuated for all outcomes except gestational diabetes (aRR: 1.76, 95% CI: 1.06-2.93).

conclusionsWomen using ADHD medications had an elevated incidence of cardiometabolic conditions during pregnancy, but it remains unclear to what extent this is attributable to medications rather than the underlying ADHD.

Indexed as

Attention Deficit Disorder with HyperactivityCentral Nervous System StimulantsDiabetes, GestationalHypertension, Pregnancy-InducedPre-EclampsiaPregnancy ComplicationsAdultCohort StudiesFemaleHumansNew South WalesPregnancyYoung AdultCentral Nervous System StimulantsADHDGestational diabetes mellitusGestational hypertensionPregnancyStimulants

Identifiers

PMID41772326
PMCPMC12953407

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.