Evidence map›Paper›PMID 41772325›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2026

Optical coherence tomography findings in multiple system atrophy: insights into disease diagnosis, clinical correlations, and dopaminergic degeneration.

Yixin Kang, Haotian Wang, Xinhui Chen, Nan Jin, Miao Chen, Yueting Chen, Wen Xu, Xiaofeng Dou, Zizhen Xie, Bo Wang and 1 more

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Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Yixin KangDepartment of Neurology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Haotian WangDepartment of Nuclear Medicine and PET-CT Center, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Xinhui ChenDepartment of Neurology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Nan JinDepartment of Neurology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Miao ChenDepartment of Neurology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Yueting ChenDepartment of Ultrasound, Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences, Hangzhou, Zhejiang, China.
Wen XuDepartment of Eye Center, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Xiaofeng DouDepartment of Nuclear Medicine and PET-CT Center, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
Zizhen XieDepartment of Neurology, Affiliated Xiaoshan Hospital, Hangzhou Normal University, Hangzhou, Zhejiang, China.
Bo Wang *Department of Neurology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China. wangke1121@zju.edu.cn.
Wei Luo *Department of Neurology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China. luoweirock@zju.edu.cn.ORCID http://orcid.org/0000-0001-6951-7698

Funding

Bureau of Science and Technology of Xiaoshan District, Hangzhou No. 2022208National Natural Science Foundation of China No.82471435Science and Technology Program of Zhejiang Province 2024C03100
6 · The paper itself

Abstract

backgroundDifferentiating multiple system atrophy (MSA) from Parkinson’s disease (PD) and progressive supranuclear palsy (PSP) remains challenging. Retinal optical coherence tomography (OCT) offers noninvasive insights into neurodegeneration but remains underexplored in MSA.

objectivesTo compare OCT-derived retinal parameters in MSA, PD, PSP, and healthy controls (HCs), evaluate associations with clinical features and dopaminergic degeneration.

methodsWe enrolled 21 MSA, 22 PD, and 23 PSP patients, plus 23 HCs. OCT measured macular and retinal nerve fiber layer thicknesses. Clinical assessments and 11C-CFT PET evaluated motor/non-motor symptoms and presynaptic dopaminergic integrity.

resultsMSA exhibited significant retinal differences compared to HCs and PSP, with subtler distinctions observed when compared to PD. Retinal thickness correlated with axial motor impairments, dysphagia, and dopaminergic uptake in the caudate nucleus.

conclusionsOCT parameters may aid in differentiating MSA from other parkinsonian syndromes and serve as a indicator linked to disease severity and dopaminergic dysfunction.

Indexed as

Multiple System AtrophyParkinson DiseaseRetinaSupranuclear Palsy, ProgressiveTomography, Optical CoherenceAgedDiagnosis, DifferentialDopamineFemaleHumansMaleMiddle AgedPositron-Emission TomographyDopamineDopaminergic imagingMultiple system atrophyOptical coherence tomographyParkinsonian syndromesRetinal indicator

Identifiers

PMID41772325

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.