Evidence map›Paper›PMID 41772221›Full record

ArticleSurgical endoscopy2026

Risk of metachronous advanced neoplasia was comparable between patients with 1-2 and 3-4 non-advanced adenomas removed during screening colonoscopy.

Zhiyu Dong, Yanglei Li, Ouyang Li, Zili Xiao, Feng Li, Tao Sun, Jun Zhou, Shuchang Xu, Danian Ji

Abstract readMulticenter StudyComparative Study
PubMed Publisher
In one paragraph

Article in Surgical endoscopy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Zhiyu Dong *Department of Gastrointestinal Endoscopy, Huadong Hospital, Fudan University, Shanghai, China.
Yanglei Li *Department of Gastrointestinal Endoscopy, Huadong Hospital, Fudan University, Shanghai, China.
Ouyang LiDepartment of Gastrointestinal Endoscopy, Huadong Hospital, Fudan University, Shanghai, China.
Zili XiaoDepartment of Gastrointestinal Endoscopy, Huadong Hospital, Fudan University, Shanghai, China.
Feng LiDepartment of Gastrointestinal Endoscopy, Huadong Hospital, Fudan University, Shanghai, China.
Tao SunDepartment of Gastrointestinal Endoscopy, Huadong Hospital, Fudan University, Shanghai, China.
Jun ZhouDepartment of Gastrointestinal Endoscopy, Huadong Hospital, Fudan University, Shanghai, China.
Shuchang XuDepartment of Gastroenterology, Tongji Hospital, Tongji University School of Medicine, Shanghai, China. xsc-students@hotmail.com.
Danian JiDepartment of Gastrointestinal Endoscopy, Huadong Hospital, Fudan University, Shanghai, China. arctg4@163.com.

Funding

National Natural Science Foundation of China 82400624Shanghai Municipal Health Commission 202440154Shanghai Municipal Health Commission 20244Y0151
6 · The paper itself

Abstract

backgroundCurrent post-polypectomy guidelines classified 3-4 non-advanced adenomas (NAAs) as carrying an intermediate risk of metachronous advanced colorectal neoplasia (ACRN), positioned between that of 1-2 NAAs and > 4 NAAs. However, emerging evidence suggested that individuals with 3-4 NAAs may have a risk comparable to those with 1-2 NAAs. This study aimed to compare the risk of metachronous ACRN between individuals with 1-2 NAAs and 3-4 NAAs.

methodsA two-center retrospective cohort study of individuals with NAAs and subsequent surveillance colonoscopy was conducted. Cox regression models were used to compare the risk of metachronous colorectal neoplasia (CRN) and ACRN between individuals with 1-2 and 3-4 NAAs.

results2955 individuals who had NAAs removed during baseline colonoscopy were included. The risk of metachronous CRN in individuals with 1-2 NAAs was significantly lower than that in those with 3-4 NAAs (adjusted HR (95% CI), 1.28(1.04-1.57)) and those with > 4 NAAs (adjusted HR (95% CI), 1.52(1.10-2.10)), while the cumulative incidence and risk of metachronous ACRN in individuals with 1-2 NAAs was comparable with that in those with 3-4 NAAs (adjusted HR (95% CI), 0.64(0.18-2.23)) and significantly lower than that in those with > 4 NAAs (adjusted HR (95% CI), 4.69(1.51-14.6)).

conclusionsIn this observational study, the risk of metachronous ACRN after removal of 1-2 and 3-4 NAAs was comparable and lower than that observed after removal of > 4 NAAs. These findings suggest that individuals with 3-4 NAAs may have a similar risk profile to those with 1-2 NAAs. Further prospective studies are warranted to determine the optimal surveillance interval for this subgroup.

Indexed as

AdenomaColonic PolypsColonoscopyColorectal NeoplasmsNeoplasms, Second PrimaryAgedEarly Detection of CancerFemaleHumansMaleMiddle AgedRetrospective StudiesRisk AssessmentRisk FactorsAdvanced colorectal neoplasiaColonoscopyNon-advanced adenomaSurveillance interval

Identifiers

PMID41772221

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.