ReviewPediatric research2026
Prenatal chemical exposures and fetal growth: a narrative review of gene-environment interactions (2025).
Review in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Prenatal exposure to lifestyle-related and environmental chemicals has been increasingly associated with adverse birth outcomes. We previously reported associations between maternal and child genetic polymorphisms and such exposures during pregnancy, focusing on active and passive smoking. This review explores how adverse maternal exposures to such chemicals, influence birth outcomes through gene-environment interactions, excluding active and passive smoking during pregnancy. Focusing on epidemiological studies, we examined the association of gene-environment interactions with maternal lifestyle-related chemicals and environmental chemicals during pregnancy on birth outcomes. Most studies were prospective birth cohorts. While genetic polymorphisms in the cytochrome P450 (CYP) and glutathione S-transferase (GST) gene families have been previously investigated, gene polymorphisms related to receptors, transporters, and signal transduction have also been examined in both mother and children. Many reports indicate significant gene-environment interactions between lifestyle-related chemicals and environmental chemicals on birth outcomes. However, the results regarding gene-environment interactions were inconsistent. Recently, new genetic polymorphisms interacting with various chemicals have been identified in epidemiological studies. Further gene-environment interaction studies are needed to better understand the genetic and biological pathways that influence the association between lifestyle-related and environmental chemical exposures during pregnancy and birth outcomes. IMPACT: Summarizes current evidence on how maternal and child genetic polymorphisms modify the effects of prenatal chemical exposures on birth outcomes. Highlights emerging genetic variants that may alter susceptibility to lifestyle-related and environmental chemicals during pregnancy. Underscores the need for further research to clarify biological pathways and guide strategies to better protect maternal and child health.
Identifiers
41772207What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.