Evidence map›Paper›PMID 41772184›Full record

ArticleCommunications biology2026

Soluble epoxide hydrolase in the liver orchestrates abdominal aortic aneurysm formation in mice.

David S Kim, Tetsuo Horimatsu, Mourad Ogbi, Brandee Goo, Hong Shi, Praneet Veerapaneni, Ronnie Chouhaita, Nicole Cyriac, Mary Moses, Rosaria Prasad and 21 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

David S Kim *Vascular Biology Center, Medical College of Georgia at Augusta University, Augusta, GA, USA.ORCID http://orcid.org/0000-0001-6896-6950
Tetsuo Horimatsu *Vascular Biology Center, Medical College of Georgia at Augusta University, Augusta, GA, USA.
Mourad OgbiVascular Biology Center, Medical College of Georgia at Augusta University, Augusta, GA, USA.
Brandee GooVascular Biology Center, Medical College of Georgia at Augusta University, Augusta, GA, USA.ORCID http://orcid.org/0000-0002-9994-6706
Hong ShiVascular Biology Center, Medical College of Georgia at Augusta University, Augusta, GA, USA.
Praneet VeerapaneniVascular Biology Center, Medical College of Georgia at Augusta University, Augusta, GA, USA.
Ronnie ChouhaitaVascular Biology Center, Medical College of Georgia at Augusta University, Augusta, GA, USA.
Nicole CyriacVascular Biology Center, Medical College of Georgia at Augusta University, Augusta, GA, USA.
Mary MosesVascular Biology Center, Medical College of Georgia at Augusta University, Augusta, GA, USA.
Rosaria PrasadVascular Biology Center, Medical College of Georgia at Augusta University, Augusta, GA, USA.
Stephen CaveVascular Biology Center, Medical College of Georgia at Augusta University, Augusta, GA, USA.ORCID http://orcid.org/0009-0006-4700-8458
Tyler W BensonVascular Biology Center, Medical College of Georgia at Augusta University, Augusta, GA, USA.
Ragheb HarbVascular Biology Center, Medical College of Georgia at Augusta University, Augusta, GA, USA.
Ghaith AboudVascular Biology Center, Medical College of Georgia at Augusta University, Augusta, GA, USA.
Hunter G SellersVascular Biology Center, Medical College of Georgia at Augusta University, Augusta, GA, USA.
Mitchell ShiversVascular Biology Center, Medical College of Georgia at Augusta University, Augusta, GA, USA.
Stephen HaighVascular Biology Center, Medical College of Georgia at Augusta University, Augusta, GA, USA.
David J FultonVascular Biology Center, Medical College of Georgia at Augusta University, Augusta, GA, USA.
Gábor CsányiVascular Biology Center, Medical College of Georgia at Augusta University, Augusta, GA, USA.ORCID http://orcid.org/0000-0002-4429-3031
Yuqing HuoVascular Biology Center, Medical College of Georgia at Augusta University, Augusta, GA, USA.
Xiaochun LongVascular Biology Center, Medical College of Georgia at Augusta University, Augusta, GA, USA.
Philip CoffeyVascular Biology Center, Medical College of Georgia at Augusta University, Augusta, GA, USA.
Richard LeeVascular Biology Center, Medical College of Georgia at Augusta University, Augusta, GA, USA.
Avirup GuhaVascular Biology Center, Medical College of Georgia at Augusta University, Augusta, GA, USA.ORCID http://orcid.org/0000-0003-0253-1174
Wenbo ZhiCenter for Biotechnology and Genomic Medicine, Medical College of Georgia at Augusta University, Augusta, GA, USA.
Lufei YoungDepartment of Physiological and Technological Nursing, College of Nursing at Augusta University, Augusta, GA, USA.ORCID http://orcid.org/0000-0001-5056-4777
Darryl C ZeldinNational Institute of Environmental Health Sciences, National Institute of Health, Research Triangle Park, Durham, NC, USA.
Sung Hee HwangDepartment of Entomology and Nematology, and UC Davis Comprehensive Cancer Center, University of California, Davis, CA, USA.
Bruce D HammockDepartment of Entomology and Nematology, and UC Davis Comprehensive Cancer Center, University of California, Davis, CA, USA.
Neal L WeintraubVascular Biology Center, Medical College of Georgia at Augusta University, Augusta, GA, USA. nweintraub@augusta.edu.
Ha Won KimVascular Biology Center, Medical College of Georgia at Augusta University, Augusta, GA, USA. hkim3@augusta.edu.ORCID http://orcid.org/0000-0001-6272-4248

Funding

SMC macropinocytosis: a novel target in atherosclerotic vascular diseaseR01HL164792 · NHLBI · AUGUSTA UNIVERSITY · PI Gabor Csanyi · 2023 to 2026
$2.2M
Hematopoietic cells and chemokine regulation in abdominal aortic aneurysm associated thrombosisK99HL181189 · NHLBI · UNIVERSITY OF CINCINNATI · PI Tyler Wendorf Benson · 2025 to 2026
$313k
NHLBI NIH HHS K99 HL181189NHLBI NIH HHS R01 HL164792
6 · The paper itself

Abstract

The liver plays an important role in cardiovascular disease by amplifying systemic inflammation, while the underlying mechanisms remain to be defined. Soluble epoxide hydrolase (sEH) is a pro-inflammatory enzyme, and pharmacological inhibition of sEH was shown to protect against various inflammatory diseases. In this study, we have identified a novel role of the liver, through expression of sEH, in the pathogenesis of abdominal aortic aneurysm (AAA). sEH expression and activity were markedly higher in mouse liver compared with aorta and further increased in the context of AAA. Pharmacological inhibition or hepatocyte-specific disruption of sEH prevented AAA formation in two animal models of AAA (angiotensin II infusion and aortic calcium chloride application in male mice), concomitant with reduced expression of complement C3 and serum amyloid A, liver-derived inflammatory factors causally linked to AAA formation. Interestingly, data from co-incubation of liver ex vivo with aorta identified galectin-3 secreted from the aneurysm-prone aorta that activates sEH in the liver. We also determined 12,13-dihydroxyoctadecenoic acid (DiHOME) and various circulating pro-inflammatory cytokines as a downstream mechanism potentially associated with hepatic sEH in the context of AAA. These novel findings provide direct evidence that bidirectional crosstalk between aorta and liver contributes to AAA via hepatic sEH.

Indexed as

Aortic Aneurysm, AbdominalEpoxide HydrolasesLiverAngiotensin IIAnimalsDisease Models, AnimalMaleMiceMice, Inbred C57BLAngiotensin IIEpoxide Hydrolases

Identifiers

PMID41772184
PMCPMC13065950

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.