Evidence map›Paper›PMID 41772090›Full record

ArticleNature cell biology2026

RNA-specific local translation is patterned by condensates for multinucleate cell growth.

Zachary M Geisterfer, Ameya P Jalihal, Sierra J Cole, Amy S Gladfelter

Abstract read
In one paragraph

Article in Nature cell biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. A phase oscillator model of cell cycles reveals nuclear density control in a branched fungal network.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Article
  5. The Polymers of Life: Exploring Cellular Function Through Polymer Concepts.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
  6. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Zachary M Geisterfer *Department of Cell Biology, Duke University, Durham, NC, USA.
Ameya P Jalihal *Department of Cell Biology, Duke University, Durham, NC, USA.
Sierra J ColeDepartment of Cell Biology, Duke University, Durham, NC, USA.
Amy S GladfelterDepartment of Cell Biology, Duke University, Durham, NC, USA. amy.gladfelter@duke.edu.ORCID http://orcid.org/0000-0002-2490-6945

Funding

United States Department of Defense | United States Air Force | AFMC | Air Force Office of Scientific Research (AF Office of Scientific Research) FA9550-20-1-0241U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) 1F32GM147989U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) 1F32GM151858U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) 1R35GM156800U.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) 7R01GM081506-13
6 · The paper itself

Abstract

Coordination between growth and nuclear division is a common cell feature. In some syncytia, nuclei divide asynchronously throughout the cell but growth occurs only at discrete locations, raising the question how the processes are locally regulated and globally coordinated. In the syncytial fungus Ashbya gossypii, both cell cycle progression and hyphal elongation require condensates formed by the protein Whi3 in complex with distinct mRNA species. Here we show that Whi3 condensates are enriched for translation regulators and are associated with local, spatially patterned translation of specific target RNAs near nuclei and growth sites. Whi3-RNA condensates can both promote and repress mRNA translation in an RNA- and condensate size-dependent manner in vitro. Condensate interfaces are sites of translation, tunable by condensate composition, RNA valency and protein charge state in vitro. Together, these data suggest that Whi3 condensates can generate a continuum of translation states that vary depending on the subcellular location and resident RNA sequences.

Indexed as

Biomolecular CondensatesCell NucleusEremotheciumFungal ProteinsProtein BiosynthesisRNA, FungalRNA, MessengerGene Expression Regulation, FungalHyphaeFungal ProteinsRNA, FungalRNA, Messenger

Identifiers

PMID41772090
PMCPMC12992109

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.