Evidence map›Paper›PMID 41772060›Full record

Trial reportNature human behaviour2026

A crowdsourced megastudy of 12 digital single-session interventions for depression in US adults.

Benjamin T Kaveladze, Jan G Voelkel, Michael N Stagnaro, Mingjing Huang, Amanda E Smock, Erin K Sullivan, Yao M Xu, Madison P McCall, Juan Pablo Zapata, Syed Ishtiaque Ahmed and 39 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Nature human behaviour, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06856668 (A Megastudy of Single-Session Interventions to Challenge Depression in American Adults), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06856668 nacompletednot on this map

A Megastudy of Single-Session Interventions to Challenge Depression in American Adults

TypeinterventionalSponsorNorthwestern UniversityRan2025 to 2025Enrolled7,505ConditionsDepression - Major Depressive DisorderArmsBehavioral Activation (Action Brings Change Project 10-Minute Version), Mindful Acceptance, Moral Elevation, Mindful Attention Skills, 5 Habits to Beat Depression
3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Identifying the active ingredients of a behavioral activation-based digital single-session intervention targeting depression.Clinical psychological science : a journal of the Association for Psychological Science · 2026
    Article
  5. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

49 authors.

Benjamin T KaveladzeNorthwestern University, Chicago, IL, USA. bkavelad@uci.edu.ORCID http://orcid.org/0000-0001-7289-5040
Jan G VoelkelCornell University, Ithaca, NY, USA.
Michael N StagnaroYale University, New Haven, CT, USA.
Mingjing HuangNorthwestern University, Chicago, IL, USA.
Amanda E SmockNorthwestern University, Chicago, IL, USA.ORCID http://orcid.org/0009-0000-1255-8149
Erin K SullivanCentral Connecticut State University, New Britain, CT, USA.
Yao M XuStanford University, Palo Alto, CA, USA.ORCID http://orcid.org/0009-0009-3538-2671
Madison P McCallUniversity of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Juan Pablo ZapataNorthwestern University, Chicago, IL, USA.
Syed Ishtiaque AhmedUniversity of Toronto, Toronto, Ontario, Canada.
Ananya BhattacharjeeUniversity of Toronto, Toronto, Ontario, Canada.
Iva GeorgievaInstitute of Philosophy and Sociology, Bulgarian Academy of Sciences, Sofia, Bulgaria.
Rosa Hernandez-RamosUniversity of California, Irvine, Irvine, CA, USA.
Kenneth S HuberCalm Health, Palo Alto, CA, USA.
Julia K JenningsUniversity of Texas at Austin, Austin, TX, USA.
Arianna C KirkVisionari Media, Santa Barbara, CA, USA.
Robert S M KnowlesKoko, San Francisco, CA, USA.
Rachel KornfieldNorthwestern University, Chicago, IL, USA.ORCID http://orcid.org/0000-0001-8542-6913
Monika Neff LindUniversity of California, Irvine, Irvine, CA, USA.
Michelle LiuLoyola University Chicago, Chicago, IL, USA.
Michael A LiutUniversity of Toronto Mississauga, Mississauga, Ontario, Canada.ORCID http://orcid.org/0000-0003-2965-5302
Alex T MariakakisUniversity of Toronto, Toronto, Ontario, Canada.
Ali M MattuMind Stuff LLC, Oakland, CA, USA.
Adam P McGuireUniversity of Texas at Tyler, Tyler, TX, USA.ORCID http://orcid.org/0000-0002-4512-1207
Jonah MeyerhoffNorthwestern University, Chicago, IL, USA.ORCID http://orcid.org/0000-0001-5149-7959
Alissa J MrazekUniversity of Texas at Austin, Austin, TX, USA.ORCID http://orcid.org/0000-0003-3178-1789
Michael D MrazekUniversity of Texas at Austin, Austin, TX, USA.
David C MohrNorthwestern University, Chicago, IL, USA.ORCID http://orcid.org/0000-0002-5443-7596
Robert R MorrisKoko, San Francisco, CA, USA.
Christopher J MosunicCalm Health, Palo Alto, CA, USA.
Hana NipUniversity of California, Irvine, Irvine, CA, USA.
Allen Olson-UrtechoStudio Bahia, Houston, TX, USA.
Jessa R PodellUniversity of Texas at Austin, Austin, TX, USA.
Dustyn S RansomUniversity of Texas at Austin, Austin, TX, USA.
Shireen L RizviAlbert Einstein College of Medicine, New York, NY, USA.
Matthew W SouthwardThe Ohio State University, Columbus, OH, USA.
Sarah Elizabeth StoecklUniversity of California, Irvine, Irvine, CA, USA.
Madison E TaylorUniversity of California, Irvine, Irvine, CA, USA.
Amy R TexterUniversity of Colorado Boulder, Boulder, CO, USA.ORCID http://orcid.org/0009-0008-7971-1361
Calvin V TowerUniversity of Texas at Austin, Austin, TX, USA.ORCID http://orcid.org/0000-0002-1284-6228
Angelique N TrotterUniversity of Texas at Austin, Austin, TX, USA.
Joseph J WilliamsUniversity of Toronto, Toronto, Ontario, Canada.
Katherine E WislockiUniversity of California, Irvine, Irvine, CA, USA.
Elijah J WoodsonUniversity of Texas at Austin, Austin, TX, USA.
John ProtzkoCentral Connecticut State University, New Britain, CT, USA.
Lorenzo Lorenzo-LuacesIndiana University Bloomington, Bloomington, IN, USA.
Stephen M SchuellerUniversity of California, Irvine, Irvine, CA, USA.
Matthew K NockHarvard University, Cambridge, MA, USA.
Jessica L SchleiderNorthwestern University, Chicago, IL, USA.

Funding

Multidisciplinary Training Program in Digital Mental HealthT32MH115882 · NIMH · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Darren Gergle, DAVID CURTIS MOHR · 2018 to 2026
$2.4M
#EverythingSucks: Understanding the bidirectional relations between vulnerability to internalizing symptoms in youth (13-20) and social mediacontentR01MH135502 · NIMH · TRUSTEES OF INDIANA UNIVERSITY · PI Johan L. Bollen, Lorenzo Lorenzo Luaces · 2024 to 2026
$1.8M
NIMH NIH HHS T32 MH115882U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01MH135502
6 · The paper itself

Abstract

Digital, self-guided, single-session interventions (SSIs) deliver structured psychological support within one interaction. Here we crowdsourced 66 diverse 10-min SSIs for depression and, with input from researchers and lived-experience experts, selected 11 for testing in a preregistered online randomized controlled trial (ClinicalTrials.gov ID: NCT06856668 ). US adults (N = 7,505) experiencing elevated depressive symptoms were randomly assigned to 1 of the 11 crowdsourced SSIs, a validated behavioural activation SSI (active comparator) or a control condition without intervention content. Nearly all SSIs improved psychological outcomes immediately after completion (d ≤ 0.37). However, only two SSIs significantly reduced depression at 4-week follow-up (d = 0.14 and 0.15). Unexpectedly, completing an SSI made participants feel less confident and less interested in making changes to overcome depression at 4 weeks, on average (d = 0.05). Future work should aim to leverage SSIs' immediate benefits to promote sustained behaviour change or service engagement.

Indexed as

Behavior TherapyCrowdsourcingDepressionAdultFemaleHumansMaleMiddle AgedTreatment OutcomeUnited States

Identifiers

PMID41772060

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.