Evidence map›Paper›PMID 41772053›Full record

ArticleNature2026

BCDX2-CX3 and DX2-CX3 complexes assemble and stabilize RAD51 filaments.

Christopher W Koo, Jiaqi Xiao, Sebastien Coassolo, Jie Liu, Christine Yu, Caleigh M Azumaya, Steven K Gore, Tommy K Cheung, Bobby Brillantes, Christopher M Rose and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Christopher W KooProtein Sciences, Genentech Inc., South San Francisco, CA, USA.
Jiaqi XiaoProtein Sciences, Genentech Inc., South San Francisco, CA, USA.
Sebastien CoassoloDiscovery Oncology, Genentech Inc., South San Francisco, CA, USA.ORCID http://orcid.org/0000-0003-3669-8650
Jie LiuDepartment of Microbiology and Molecular Genetics, University of California, Davis, CA, USA.ORCID http://orcid.org/0000-0001-5817-9144
Christine YuProtein Sciences, Genentech Inc., South San Francisco, CA, USA.
Caleigh M AzumayaProtein Sciences, Genentech Inc., South San Francisco, CA, USA.ORCID http://orcid.org/0000-0002-3484-9921
Steven K GoreDepartment of Microbiology and Molecular Genetics, University of California, Davis, CA, USA.ORCID http://orcid.org/0009-0003-4901-7671
Tommy K CheungProteomic & Genomic Technologies, Genentech Inc., South San Francisco, CA, USA.
Bobby BrillantesProtein Sciences, Genentech Inc., South San Francisco, CA, USA.
Christopher M RoseProteomic & Genomic Technologies, Genentech Inc., South San Francisco, CA, USA.
Wolf-Dietrich HeyerDepartment of Microbiology and Molecular Genetics, University of California, Davis, CA, USA.ORCID http://orcid.org/0000-0002-7774-1953
Claudio CiferriProtein Sciences, Genentech Inc., South San Francisco, CA, USA. ciferric@gene.com.ORCID http://orcid.org/0000-0002-0804-2411
Stanislau YatskevichProtein Sciences, Genentech Inc., South San Francisco, CA, USA. yatskevs@gene.com.ORCID http://orcid.org/0000-0003-2999-6561

Funding

RECOMBINATIONAL MECHANISMS OF DNA REPAIR IN EUKARYOTESR01GM058015 · NIGMS · UNIVERSITY OF CALIFORNIA DAVIS · PI HEYER, WOLF-DIETRICH · 2000 to 2025
$8.8M
Roles of BRCA2 in Mammalian Meiosis and Gamete QualityR01HD109322 · NICHD · UNIVERSITY OF CALIFORNIA AT DAVIS · PI NEIL HUNTER, Wolf-Dietrich Heyer · 2024 to 2026
$2.0M
Regulation of DNA double-strand break repair pathway choiceR01CA273911 · NCI · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Wolf-Dietrich Heyer · 2023 to 2026
$1.9M
Mechanisms of Recombinational DNA RepairR35GM157976 · NIGMS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI Wolf-Dietrich Heyer · 2025 to 2026
$957k
NCI NIH HHS R01 CA273911NICHD NIH HHS R01 HD109322NIGMS NIH HHS R01 GM058015NIGMS NIH HHS R35 GM157976
6 · The paper itself

Abstract

The repair of DNA double-strand breaks by homologous recombination is essential for genomic integrity, and its dysregulation is a hallmark of cancer

Indexed as

DNA-Binding ProteinsMultiprotein ComplexesRad51 RecombinaseAdenosine TriphosphateCryoelectron MicroscopyDNA, Single-StrandedHomologous RecombinationHumansModels, MolecularAdenosine TriphosphateDNA-Binding ProteinsDNA, Single-StrandedMultiprotein ComplexesRAD51B protein, humanRAD51C protein, humanRAD51D protein, humanRAD51 protein, humanRad51 RecombinaseX-ray repair cross complementing protein 3XRCC2 protein, human

Identifiers

PMID41772053
PMCPMC13537095

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.