Evidence map›Paper›PMID 41772048›Full record

ArticleScientific reports2026

Propofol and dexmedetomidine sedation share the similar functional activity but distinct functional synchronization.

Jian Minyu, Zhang Jiayi, Li Guiyu, Han Ruquan, Wang Chengwei, Liang Fa, Ma Bo, Li Yang, Wang Xuejun, Zong Fangrong and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jian MinyuDepartment of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, No. 119, Southwest 4th Ring Road, Fengtai District, Beijing, 100070, China.
Zhang JiayiSchool of Artificial Intelligence, Beijing University of Posts and Telecommunications, Beijing, China.
Li GuiyuDepartment of Anesthesiology, Qinghai University Affiliated Hospital, Qinghai University, Xining, Qinghai, China.
Han RuquanDepartment of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, No. 119, Southwest 4th Ring Road, Fengtai District, Beijing, 100070, China.
Wang ChengweiDepartment of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, No. 119, Southwest 4th Ring Road, Fengtai District, Beijing, 100070, China.
Liang FaDepartment of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, No. 119, Southwest 4th Ring Road, Fengtai District, Beijing, 100070, China.
Ma BoDepartment of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, No. 119, Southwest 4th Ring Road, Fengtai District, Beijing, 100070, China.
Li YangDepartment of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, No. 119, Southwest 4th Ring Road, Fengtai District, Beijing, 100070, China.
Wang XuejunDepartment of Anesthesiology, Qinghai Red Cross Hospital, Xining, Qinghai, China.
Zong FangrongSchool of Artificial Intelligence, Beijing University of Posts and Telecommunications, Beijing, China.
Liu HaiyangDepartment of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, No. 119, Southwest 4th Ring Road, Fengtai District, Beijing, 100070, China. oceantth@163.com.

Funding

Beijing Hospital Management Center Youth Talent Development Program QML20230509National Natural Science Foundation of China 82271284National Natural Science Foundation of China 82371910
6 · The paper itself

Abstract

There is insufficient unified research on the effects of propofol and dexmedetomidine on brain functional activity and synchronization. We collected resting-state functional magnetic resonance imaging data from 21 healthy subjects in four different levels of consciousness induced by propofol (awake, mild sedation, deep sedation, and recovery), and other 21 healthy subjects in three different levels of consciousness induced by dexmedetomidine (awake, mild sedation and recovery). The results showed that with the increasing of sedation levels of propofol or dexmedetomidine, fractional amplitude of low-frequency fluctuations and regional homogeneity values decreased in the frontal lobe, while they increased in the superior temporal gyrus and paracentral lobule. Under propofol sedation, functional connectivity (FC) decreased both within and between sensorimotor network and attention network, and within and between the frontoparietal network (FPN) and default mode network (DMN). Simultaneously, a small number of increased connections were observed between the FPN, DMN, and other networks. Under dexmedetomidine sedation, generally decreased FC was observed in the whole brain. This study shows consistent effects on brain functional activity, but distinct impacts on functional synchronization, providing new insights into the understanding of anesthetic mechanisms.

Indexed as

BrainDexmedetomidineHypnotics and SedativesPropofolAdultBrain MappingConsciousnessFemaleHumansMagnetic Resonance ImagingMaleYoung AdultDexmedetomidineHypnotics and SedativesPropofolDexmedetomidineFunctional activityFunctional magnetic resonance imagingFunctional synchronizationPropofol

Identifiers

PMID41772048
PMCPMC13066524

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.