Evidence map›Paper›PMID 41771899›Full record

ArticleNature communications2026

Reversible surface modifications of functional proteins for accelerated cytosolic delivery via cell-penetrating peptide clusters.

Xiao Hua, Yanyan Guo, Pincheng Li, Yu Wang, Xiaona Han, Junyou Chen, Junjiang Li, Guo-Chao Chu, Jing Shi, Lei Liu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xiao Hua *School of Food and Biological Engineering, Engineering Research Center of Bioprocess, Ministry of Education, Key Laboratory of Animal Source of Anhui Province, Hefei University of Technology, Hefei, 230009, China.
Yanyan Guo *Department of Chemistry, University of Science and Technology of China, Hefei, 230026, China.
Pincheng Li *School of Food and Biological Engineering, Engineering Research Center of Bioprocess, Ministry of Education, Key Laboratory of Animal Source of Anhui Province, Hefei University of Technology, Hefei, 230009, China.
Yu Wang *School of Food and Biological Engineering, Engineering Research Center of Bioprocess, Ministry of Education, Key Laboratory of Animal Source of Anhui Province, Hefei University of Technology, Hefei, 230009, China.
Xiaona HanSchool of Food and Biological Engineering, Engineering Research Center of Bioprocess, Ministry of Education, Key Laboratory of Animal Source of Anhui Province, Hefei University of Technology, Hefei, 230009, China.
Junyou ChenSchool of Food and Biological Engineering, Engineering Research Center of Bioprocess, Ministry of Education, Key Laboratory of Animal Source of Anhui Province, Hefei University of Technology, Hefei, 230009, China.
Junjiang LiSchool of Food and Biological Engineering, Engineering Research Center of Bioprocess, Ministry of Education, Key Laboratory of Animal Source of Anhui Province, Hefei University of Technology, Hefei, 230009, China.
Guo-Chao ChuSchool of Food and Biological Engineering, Engineering Research Center of Bioprocess, Ministry of Education, Key Laboratory of Animal Source of Anhui Province, Hefei University of Technology, Hefei, 230009, China.
Jing ShiDepartment of Chemistry, University of Science and Technology of China, Hefei, 230026, China.
Lei LiuTsinghua-Peking Center for Life Sciences, Ministry of Education Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Center for Synthetic and Systems Biology, Department of Chemistry, Tsinghua University, Beijing, 100084, China. lliu@mail.tsinghua.edu.cn.ORCID http://orcid.org/0000-0001-6290-8602
Yi-Ming LiSchool of Food and Biological Engineering, Engineering Research Center of Bioprocess, Ministry of Education, Key Laboratory of Animal Source of Anhui Province, Hefei University of Technology, Hefei, 230009, China. ymli@hfut.edu.cn.ORCID http://orcid.org/0000-0001-6716-8199

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A long-standing goal in biomedical research is to label and manipulate intracellular targets, which could be achieved through the cytosolic delivery of exogenous functional proteins. The development of Tat clusters has advanced the nontoxic intracellular delivery of functional antibodies at low concentrations, but the variety of proteins that can be successfully delivered remains limited. Here, we find that by simply reversibly modifying the surface of functional proteins with anionic peptide patches, various protein cargoes (which are normally difficult to deliver) can be delivered into living cells by synergetic electrostatic interactions with the cationic cell-penetrating peptide clusters TAT

Indexed as

Cell-Penetrating PeptidesCytosolProteinsAnimalsHumansProtein Processing, Post-TranslationalProtein TransportCell-Penetrating PeptidesProteins

Identifiers

PMID41771899
PMCPMC13065835

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.