ArticleSignal transduction and targeted therapy2026
GPR54 regulates non-small cell lung cancer development via dopa decarboxylase.
Article in Signal transduction and targeted therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Non-small cell lung cancer (NSCLC), the most common type of lung cancer, is a leading cause of cancer death. G protein-coupled receptor 54 (GPR54) plays a role in cancer development by interacting with its endogenous ligand kisspeptin encoded by the KISS1 gene. However, the role of GPR54 in NSCLC development is not yet fully understood. Here, we demonstrate that GPR54 regulates NSCLC development via dopa decarboxylase (DDC). A mutant Kras-driven mouse lung cancer model revealed that adenoviral CMV-Cre-mediated Gpr54 deletion attenuated NSCLC development. Both Gpr54 deletion in mouse NSCLC tissues and GPR54 knockdown in human NSCLC cell lines caused apoptotic cell death. In addition, GPR54 regulation of NSCLC cell proliferation involves both the Gα
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