Evidence map›Paper›PMID 41771817›Full record

ArticleChemistry & biodiversity2026

Isolation, RP-UHPLC-ESI-LIT-Orbitrap-MS/MS-Based Metabolic Profiling and Anticandidal Activity of the Root and Leaf Secondary Metabolites of Monotes Kerstingii Gilg (Dipterocarpaceae).

Sorelle Kache Fotsing, Dominique Ngnintedo, Yanick Kevin Dongmo Melogmo, Alena Soboleva, Kevine Dongmo Jumeta, Bruno Ndjakou Lenta, Fabrice Fekam Boyom, Andrej Frolov, Norbert Arnold, Ludger A Wessjohann and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Sorelle Kache FotsingDepartment of Organic Chemistry, Faculty of Science, University of Yaoundé 1, Yaoundé, Cameroon.
Dominique NgnintedoDepartment of Organic Chemistry, Faculty of Science, University of Yaoundé 1, Yaoundé, Cameroon.
Yanick Kevin Dongmo MelogmoDepartment of Biochemistry, Faculty of Science, University of Yaoundé 1, Yaoundé, Cameroon.
Alena SobolevaDepartment of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Halle (Saale), Germany.
Kevine Dongmo JumetaDepartment of Chemistry, Higher Teacher Training College, University of Yaoundé 1, Yaoundé, Cameroon.
Bruno Ndjakou LentaDepartment of Chemistry, Higher Teacher Training College, University of Yaoundé 1, Yaoundé, Cameroon.
Fabrice Fekam BoyomDepartment of Biochemistry, Faculty of Science, University of Yaoundé 1, Yaoundé, Cameroon.ORCID https://orcid.org/0000-0002-3147-364X
Andrej FrolovDepartment of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Halle (Saale), Germany.
Norbert ArnoldDepartment of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Halle (Saale), Germany.
Ludger A WessjohannDepartment of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Halle (Saale), Germany.
Norbert SewaldDepartment of Organic Chemistry, Faculty of Science, University of Bielefeld, Bielefeld, Germany.
Bonaventure Tchaleu NgadjuiDepartment of Organic Chemistry, Faculty of Science, University of Yaoundé 1, Yaoundé, Cameroon.
Ghislain Wabo FotsoDepartment of Organic Chemistry, Faculty of Science, University of Yaoundé 1, Yaoundé, Cameroon.ORCID https://orcid.org/0000-0003-3815-0883

Funding

YaBiNaPA 57561808
6 · The paper itself

Abstract

The anticandidal activity of Monotes kerstingii leaf and root crude extracts was evaluated against five clinical Candida isolates: C. albicans, C. parapsilosis, C. krusei, C. glabrata and C. tropicalis. Extracts from both organs displayed Minimal Inhibitory Concentrations (MICs) ranging from 3.9 to 2000 µg/mL. Out of the five Candida species, the leaf hydroethanolic extract (EMKL) was the most active with MIC values of 3.9, 15.6 and 31.5 µg/mL on C. krusei, C. parapsilosis and C. albicans, respectively. The chemical investigation of these extracts led to the characterization of six previously undescribed metabolites, including a glycosylated stilbene: kerstingioside (1), three cis stilbene-coumarins: cis-kerstilbcoumarin A-C (2-4) among which two as inseparable cis/trans-mixtures, one flavanone: kerstingiiflavanone (5) and one fatty acid glycoside, monestoside B (6), alongside with 22 known compounds. The distribution of the annotated metabolites in the roots and leaves was confirmed by comprehensive RP-UHPLC-Orbitrap-MS and MS/MS analysis. In addition, all the isolated compounds were screened for their anticandidal activity. Stilbene 7 was the most active constituent, with MICs of 7.8, 15.6, and 15.6 µg/mL against C. albicans, C. krusei, and C. parapsilosis, respectively, while compounds 14 and 15 exhibited only moderate activity.

Indexed as

Antifungal AgentsCandidaPlant ExtractsPlant LeavesPlant RootsChromatography, High Pressure LiquidMicrobial Sensitivity TestsMolecular StructureSecondary MetabolismSpectrometry, Mass, Electrospray IonizationTandem Mass SpectrometryAntifungal AgentsPlant Extractsanticandidal activitycis‐kerstilbcoumarin A–CkerstingiiflavanonekerstingiosideM. kerstingiiMonestoside B

Identifiers

PMID41771817
PMCPMC12953213

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.