Evidence map›Paper›PMID 41771720›Full record

ArticleTrends in immunology2026

Decidual immune activation by extravillous trophoblasts drives maternal-fetal tolerance and immunity.

Tamara Tilburgs

Abstract read
In one paragraph

Article in Trends in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Tamara TilburgsDivision of Immunobiology, Cincinnati Children's Hospital, Cincinnati, OH, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, USA.

Funding

Maternal microbial exposure fundamentally shapes the CD8 T cell population at the maternal fetal interfaceR01AI189469 · NIAID · UNIVERSITY OF MINNESOTA · PI SCHULDT, NATHAN · 2025 to 2025
$3.0M
The role of HLA-C in chronic chorioamnionitisR01HD116852 · NICHD · CINCINNATI CHILDRENS HOSP MED CTR · PI Tamara Tilburgs · 2025 to 2026
$1.2M
NIAID NIH HHS R01 AI189469NICHD NIH HHS R01 HD116852
6 · The paper itself

Abstract

During pregnancy, complex interactions of maternal immune cells and fetal extravillous trophoblasts (EVTs) orchestrate placentation, immune tolerance, and immune defense. This forum article highlights important discoveries and outstanding questions on how the activation of decidual natural killer and T cells, through recognition of key EVT ligands, promotes placentation, tolerance, and immunity.

Indexed as

DeciduaExtravillous TrophoblastsImmune ToleranceMaternal-Fetal ExchangeTrophoblastsAnimalsFemaleHumansKiller Cells, NaturalPlacentationPregnancycytotoxicityextravillous trophoblastsHLA-Cnatural killer cellsregulatory T cells

Identifiers

PMID41771720
PMCPMC12959355

What OpenQuestion holds

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LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.