ArticleACS chemical neuroscience2026
Fluorescence Detection of Alpha-Synuclein Aggregates in the Gut Using a Peptide Probe.
Article in ACS chemical neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Parkinson's disease (PD) is diagnosed clinically by motor symptoms, with no clinical molecular diagnostic test currently available. By the time motor symptoms manifest, significant irreversible neurodegeneration would have already occurred, limiting the effectiveness of the therapies. Recent identification of pathological α-synuclein (α-syn) aggregates in the gastrointestinal tract of prodromal PD patients offers a potential avenue for early diagnosis. This study aims to explore specific fluorescence labeling of α-syn aggregates in the gastrointestinal tract using a peptide-based probe for early indication of PD risk. We used primary hippocampal neuronal cells and wild-type mouse tissues with the addition of preformed α-syn fibrils (PFFs) to identify the most suitable probe (
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