ReviewInternational braz j urol : official journal of the Brazilian Society of Urology
The WHO 2025 Guideline for the Prevention, Diagnosis and Treatment of Infertility: A Comprehensive Review with Focus on Male Reproductive Health.
Review in International braz j urol : official journal of the Brazilian Society of Urology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed.
- Androgen rapidly activates phosphorylation signaling pathways in Sertoli cells.Experimental and therapeutic medicine · 2026Article
- Associations of anxiety and depression with sexual health among infertility patients: a systematic review.Frontiers in psychology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Infertility affects millions worldwide and is increasingly recognized as a major public-health concern. Despite advances in reproductive medicine, the lack of a unified global framework has contributed to substantial heterogeneity in clinical practice, particularly in the evaluation and management of male infertility. In 2025, the World Health Organization (WHO) issued its first comprehensive Guideline for the Prevention, Diagnosis, and Treatment of Infertility, establishing a global, evidence-based standard applicable across diverse resource settings. Notably, the guideline integrates male reproductive health throughout prevention, diagnosis, and treatment pathways, reinforcing the essential role of paternal factors in reproductive outcomes. This review summarizes the development, scope, and methodological foundations of the WHO guideline, including its use of systematic evidence synthesis, the GRADE framework, and structured consensus processes. Particular emphasis is placed on male-focused recommendations and good practice statements on lifestyle risk modification, sexually transmitted infections, standardized semen analysis, diagnostic algorithms, unexplained infertility, antioxidant supplementation, and varicocele repair. The review also clarifies the guideline's public-health scope and delineates areas that remain within the domain of specialty practice. Finally, we discuss dissemination, implementation challenges, and research priorities, highlighting persistent evidence gaps in male reproductive biology, sperm function, and clinically meaningful treatment outcomes. By aligning public-health principles with contemporary understanding of male physiology, the WHO guideline provides a global foundation for equitable and systematic infertility care.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.