Evidence map›Paper›PMID 41770502›Full record

ArticleInflammopharmacology2026

Essential oil from Eugenia stipitata McVaugh leaves exhibits antinociceptive effect via opioid receptor activation.

Wêndeo Kennedy Costa, Priscilla Glazielly Dos Santos de Moraes, João Guilherme Euzebio Souza, Paulo Henrique Andrade do Nascimento Silva, Hilary Araujo Dantas, Erica Kaylane da Silva, Laís Ruanita Leopoldina Galvão, Tamyres Suellen da Silva Freitas, Thaís Vitória Freitas de Souza, Alisson Macário de Oliveira and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Inflammopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Wêndeo Kennedy CostaDepartamento de Bioquímica, Universidade Federal de Pernambuco, Recife, PE, 50670-901, Brazil. wendeocosta@gmail.com.
Priscilla Glazielly Dos Santos de MoraesDepartamento de Bioquímica, Universidade Federal de Pernambuco, Recife, PE, 50670-901, Brazil.
João Guilherme Euzebio SouzaDepartamento de Bioquímica, Universidade Federal de Pernambuco, Recife, PE, 50670-901, Brazil.
Paulo Henrique Andrade do Nascimento SilvaDepartamento de Bioquímica, Universidade Federal de Pernambuco, Recife, PE, 50670-901, Brazil.
Hilary Araujo DantasDepartamento de Bioquímica, Universidade Federal de Pernambuco, Recife, PE, 50670-901, Brazil.
Erica Kaylane da SilvaDepartamento de Bioquímica, Universidade Federal de Pernambuco, Recife, PE, 50670-901, Brazil.
Laís Ruanita Leopoldina GalvãoDepartamento de Bioquímica, Universidade Federal de Pernambuco, Recife, PE, 50670-901, Brazil.
Tamyres Suellen da Silva FreitasDepartamento de Bioquímica, Universidade Federal de Pernambuco, Recife, PE, 50670-901, Brazil.
Thaís Vitória Freitas de SouzaDepartamento de Bioquímica, Universidade Federal de Pernambuco, Recife, PE, 50670-901, Brazil.
Alisson Macário de OliveiraPrograma de Pós-graduação em Ciências Farmacêuticas, Universidade Estadual da Paraíba, Campina Grande, PB, 58429-500, Brazil.
Márcia Vanusa da SilvaDepartamento de Bioquímica, Universidade Federal de Pernambuco, Recife, PE, 50670-901, Brazil.
Maria Tereza Dos Santos CorreiaDepartamento de Bioquímica, Universidade Federal de Pernambuco, Recife, PE, 50670-901, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Eugenia stipitata McVaugh, a species of the Myrtaceae family, is widely distributed in tropical regions and has traditionally been used by local communities to treat mouth and throat inflammation, stomach pain, wounds, fever, diarrhea, and other inflammatory conditions. This study aimed to investigate the effects of the essential oil from E. stipitata (EsEO) in experimental pain models in mice, evaluating its potential as an alternative analgesic therapy. Mice were treated with EsEO and tested in formalin, tail immersion, and hot plate models to assess antinociceptive effects. Pharmacological antagonists were used to investigate the mechanism, suggesting opioid receptor involvement. Behavioral responses and latencies were measured post-treatment. EsEO significantly reduced neurogenic and inflammatory pain responses in all tests. In the formalin test, both early and late phases showed decreased pain behaviors. Similar reductions were observed in the tail immersion and hot plate tests. The major constituents appear to exert both central and peripheral analgesic effects. The use of antagonists indicated that the antinociceptive mechanism of the essential oil involves, at least in part, the modulation of the opioid pathway. EsEO exhibited significant antinociceptive activity and presents itself as a promising natural alternative for pain management. These findings support further research into the mechanisms and therapeutic potential of natural products for the development of safer and more effective analgesics.

Indexed as

AnalgesicsEugeniaOils, VolatilePainPlant LeavesReceptors, OpioidAnimalsDisease Models, AnimalMaleMicePain MeasurementPlant ExtractsAnalgesicsOils, VolatilePlant ExtractsReceptors, OpioidAnalgesiaEssential oilsInflammatory painOpioid receptorsPain

Identifiers

PMID41770502
PMCPMC13083384

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.