ArticleInflammopharmacology2026
Effects of Pelargonium sidoides root extract on paw oedema, nitric oxide signaling, and synovial vascular changes in a rat model of adjuvant-induced arthritis.
Article in Inflammopharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rheumatoid arthritis (RA) is characterized by chronic synovitis with pannus formation and progressive joint destruction. Pannus growth relies on angiogenesis, and nitric oxide (NO) contributes to vascular and inflammatory signaling. Although Pelargonium sidoides (PS) has not been evaluated in experimental arthritis, prior work suggests that PS can modulate NO production in activated macrophages. Arthritis was induced with complete Freund's adjuvant (CFA) on day 0. On day 17, rats with ≥ 5% paw swelling were treated. From day 17 to day 27, rats received daily oral P. sidoides (100, 200, or 500 mg/kg), ibuprofen (100 mg/kg), or vehicle. Paw diameter was recorded during treatment. On day 27, tissues were collected for histopathology (inflammation, angiogenesis, granuloma formation, synovial hyperplasia) and blood was analysed for nitrite/nitrate (NOx) and oxidative/antioxidant markers (asymmetric dimethylarginine (ADMA), malondialdehyde (MDA), superoxide dismutase (SOD), catalase, and glutathione). All doses of P. sidoides reduced paw oedema. The 200 mg/kg dose resulted in NOx levels and synovial microvessel densities that were numerically closer to healthy control values; however, these improvements did not reach statistical significance when compared directly to the vehicle group. Other oxidative markers showed no consistent changes. Plasma glutathione decreased across PS-treated groups without accompanying increases in MDA or body-weight loss, which is compatible with increased utilization during phytochemical clearance rather than overt systemic toxicity. In conclusion, P. sidoides improved macroscopic swelling in adjuvant arthritis and, at 200 mg/kg, showed numerical shifts toward control-like values in plasma NOx and synovial microvessel density, although studies with greater statistical power are needed to confirm these exploratory tissue-level signals.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.