ArticleActa parasitologica2026
Lipid Metabolomics Analysis of a Rosacea Animal Model Induced by Demodex Mite Extract.
Article in Acta parasitologica, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
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Corrections and comments
- Erratum issued
Authors and funding
10 authors.
Funding
Abstract
objectiveThe contribution of Demodex folliculorum to rosacea pathogenesis was investigated using a murine model.
methodsMite-derived proteins were extracted following collection via adhesive tape. A rosacea mouse model was established, and mice received intradermal injections at identical dorsal sites with Cathelicidin antimicrobial peptide LL-37 (LL-37) group, Demodex protein extract (extract group), a combination of LL-37 and extract (mixed group), or phosphate-buffered saline (PBS group). On day 17 post-injection, lesional skin was harvested for hematoxylin and eosin (H&E) staining, lipidomic profiling, and western blotting.
resultsHE staining showed that lymphocyte infiltration and increased adipocytes were observed in the extract group, LL-37 group, and combination group. Lipid metabolomics identified 2604 differential metabolites. Triglyceride (TG) 24:5/16:0/18:1, Monoglyceride (MG) 18:4, MG (19:4), and Phosphatidylcholine (PC) 44:6e were significantly increased in the extract group, LL-37 group, and combination group. Glycerophospholipid metabolism and thermogenesis pathways were enriched in the extract group, LL-37 group, and combination injection group, with the most significant enrichment in the combination injection group. The protein expression levels of Phosphorylated AKT (P-AKT) and Phosphorylated FOXO1 (P-FOXO1) were highest in the combination injection group.
conclusionDemodex mites promote the upregulation of P-AKT and P-FOXO1 by synergistically activating the Phosphoinositide 3-Kinase (PI3K)-AKT-FOXO1 pathway, which enhances lipid synthesis, leads to lipid metabolism disorders and skin barrier damage, thereby exacerbating the progression of rosacea.
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Registered trials
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