Evidence map›Paper›PMID 41770250›Full record

ArticleBiogerontology2026

Erzhi pills: a potential aging-modulating agent targeting immunosenescence in mice.

Zhirui Fang, Wei Sun, Na Li, Tingting Shi, Xiuyun Ren, Rui Zhang, Yujing Zhang, Jing Chen, Qi Liu, Meng Wang and 2 more

Abstract read
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In one paragraph

Article in Biogerontology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Zhirui Fang *Instrumental Analysis and Research Center, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
Wei Sun *School of Medical Technology, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
Na Li *State Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
Tingting ShiSchool of Medical Technology, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
Xiuyun RenSchool of Medical Technology, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
Rui ZhangSchool of Medical Technology, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
Yujing ZhangSchool of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
Jing ChenDepartment of Dermatology, Second Affiliated Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, 300250, China.
Qi LiuSchool of Medical Technology, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China.
Meng WangState Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China. mengwangr@163.com.
Lu ChenInstrumental Analysis and Research Center, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China. chenlutjutcm@tjutcm.edu.cn.
Hong WangSchool of Medical Technology, Tianjin University of Traditional Chinese Medicine, Tianjin, 301617, China. wanghongsys@tjutcm.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Erzhi Pills (EZP), a traditional Chinese herbal formula, has demonstrated potential aging-modulating properties, while its mechanisms in modulating immunosenescence remain incompletely understood. Two complementary aging murine models were employed to investigate the anti-immunosenescence efficacy of EZP, providing experimental validation for its translational application in delaying age-related immune decline. Morphological and physiological parameters were monitored and thymic/splenic organ coefficients were calculated. Histopathological evaluation of thymic involution was performed via hematoxylin-eosin (H&E) staining. Flow cytometry quantified splenic T cell subsets (naïve/memory CD4

Indexed as

AgingDrugs, Chinese HerbalImmunosenescenceAnimalsCytokinesMaleMiceMice, Inbred C57BLSpleenThymus GlandCytokinesDrugs, Chinese HerbalErzhi PillsImmune senescenceImmunometabolic regulationT cells

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.