Evidence map›Paper›PMID 41770249›Full record

ArticleAntimicrobial agents and chemotherapy2026

Single-ascending and multiple-ascending dose study of the pharmacokinetics, safety, and tolerability of BV100 (rifabutin for infusion) in healthy volunteers.

Christian Kemmer, Martin Hirsch, Christian Reh, Myriam Davila, Françoise Jung, Lisa Husband, Glenn E Dale

Abstract readClinical Trial, Phase I
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Christian KemmerBioVersys AG, Basel, Switzerland.
Martin HirschNuvisan GmbH, Neu-Ulm, Bavaria, Germany.
Christian RehNuvisan GmbH, Neu-Ulm, Bavaria, Germany.
Myriam DavilaTFS, Barcelona, Spain.
Françoise JungBioVersys AG, Basel, Switzerland.ORCID 0009-0002-2731-0327
Lisa HusbandTFS, Barcelona, Spain.ORCID 0009-0006-8791-8923
Glenn E DaleBioVersys AG, Basel, Switzerland.ORCID 0009-0009-6990-2030

Funding

BioVersys AG., Basel, Switzerland
6 · The paper itself

Abstract

BV100 (rifabutin for infusion) is being developed as an intravenous formulation for treating serious or life-threatening infections due to carbapenem-resistant

Indexed as

Anti-Bacterial AgentsRifabutinAdolescentAdultDose-Response Relationship, DrugFemaleHealthy VolunteersHumansInfusions, IntravenousMaleMiddle AgedYoung AdultAnti-Bacterial AgentsRifabutinBV100pharmacokineticsrifabutin

Identifiers

PMID41770249
PMCPMC13041365

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.