Evidence map›Paper›PMID 41770241›Full record

ReviewCurrent atherosclerosis reports2026

Triglyceride-Rich Lipoproteins and Inflammation: Independent and Synergistic Roles in Cardiovascular Disease.

Ask Tybjærg Nordestgaard

Abstract readReview
PubMed Publisher
In one paragraph

Review in Current atherosclerosis reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Ask Tybjærg NordestgaardDivision of Preventive Medicine, Brigham and Women's Hospital, 900 Commonwealth Avenue, Boston, MA, 02139, USA. anordestgaard@mgh.harvard.edu.

Funding

The Independent Research Fund Denmark 10.46540/3165-00227B
6 · The paper itself

Abstract

purpose of reviewTo summarize novel insights regarding the independent and combined roles of triglyceride-rich lipoprotein elevations and low-grade inflammation in cardiovascular disease. RECENT

findingsEmerging evidence suggest that triglyceride-rich lipoproteins are more atherogenic than LDL particles, and that remnant cholesterol drives the association with cardiovascular risk. In contemporary secondary prevention, elevated hsCRP is a stronger predicter of cardiovascular events than LDL cholesterol, while in primary prevention, hsCRP and LDL cholesterol equally predict risk of future cardiovascular disease. Some anti-inflammatory trials do not support the use of colchicine in acute coronary syndrome; however, results from recent meta-analyses strongly support colchicine therapy for secondary cardiovascular prevention. Finally, epidemiological and genetic studies indicate that triglyceride-rich lipoproteins cause vascular inflammation, although both risk factors appear to contribute synergistically to cardiovascular risk. Triglyceride-rich lipoprotein elevations and low-grade inflammation are important, independent cardiovascular risk factors. More research is needed to further characterize their potential interplay in cardiovascular disease and validate never therapies.

Indexed as

Cardiovascular DiseasesInflammationLipoproteinsTriglyceridesColchicineC-Reactive ProteinHeart Disease Risk FactorsHumansRisk FactorsColchicineC-Reactive ProteinLipoproteinslipoprotein triglycerideTriglyceridesCardiovascular diseaseHigh-sensitivity C-reactive proteinInflammationRemnant cholesterolTriglyceride-rich lipoproteinsTriglycerides

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.