Evidence map›Paper›PMID 41770228›Full record

ArticleAntimicrobial agents and chemotherapy2026

Population pharmacokinetics of pyrazinamide and ethambutol in children with tuberculosis with or without HIV.

Nicole F Maranchick, Charles Martyn-Dickens, Anthony Enimil, Hongmei Yang, Aikins Kofi Amissah, Albert Dompreh, Dennis Bosomtwe, Eugenia Sly-Moore, Theresah Opoku, Augustina Frimpong Appiah and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Nicole F MaranchickInfectious Disease Pharmacokinetics Laboratory, College of Pharmacy and Emerging Pathogens Institute, University of Florida, Gainesville, Florida, USA.ORCID 0009-0002-3051-7062
Charles Martyn-DickensDirectorate of Child Health, Komfo Anokye Teaching Hospital, Kumasi, Ghana.
Anthony EnimilDirectorate of Child Health, Komfo Anokye Teaching Hospital, Kumasi, Ghana.
Hongmei YangDepartment of Biostatistics and Computational Biology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA.
Aikins Kofi AmissahDirectorate of Child Health, Komfo Anokye Teaching Hospital, Kumasi, Ghana.
Albert DomprehDepartment of Clinical Microbiology, Komfo Anokye Teaching Hospital, Kumasi, Ghana.
Dennis BosomtweDirectorate of Child Health, Komfo Anokye Teaching Hospital, Kumasi, Ghana.
Eugenia Sly-MooreDirectorate of Child Health, Komfo Anokye Teaching Hospital, Kumasi, Ghana.
Theresah OpokuDirectorate of Child Health, Komfo Anokye Teaching Hospital, Kumasi, Ghana.
Augustina Frimpong AppiahDirectorate of Child Health, Komfo Anokye Teaching Hospital, Kumasi, Ghana.
Priscilla AsieduDepartment of Pharmacy, Komfo Anokye Teaching Hospital, Kumasi, Ghana.
Sampson AntwiDirectorate of Child Health, Komfo Anokye Teaching Hospital, Kumasi, Ghana.
Marc H ScheetzDepartment of Pharmacy Practice, College of Pharmacy, Midwestern University, Downers Grove, Illinois, USA.ORCID 0000-0002-1091-6130
Charles A PeloquinInfectious Disease Pharmacokinetics Laboratory, College of Pharmacy and Emerging Pathogens Institute, University of Florida, Gainesville, Florida, USA.
Awewura KwaraDepartment of Medicine, University of Florida College of Medicine, Gainesville, Florida, USA.ORCID 0000-0002-1118-8331

Funding

Pharmacokinetics of Anti-tuberculosis and Antiretroviral Drugs in ChildrenR01HD071779 · NICHD · UNIVERSITY OF FLORIDA · PI KWARA, AWEWURA JACOB · 2012 to 2022
$6.0M
Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) at the National Institutes of Health (NIH) HD071779NICHD NIH HHS R01 HD071779
6 · The paper itself

Abstract

Tuberculosis (TB) is a major cause of morbidity and mortality in children globally. This study developed models to describe population pharmacokinetics (PK) of pyrazinamide (PZA) and ethambutol (EMB) in children with TB with or without human immunodeficiency virus (HIV) coinfection. Ghanaian children with TB with or without HIV coinfection receiving first-line antituberculosis therapy for at least 4 weeks had blood samples collected at time 0 (pre-dose), 1-, 2-, 4-, 8-, and 12-h post-dose. PZA and EMB concentrations were quantified using liquid chromatography tandem mass spectrometry. Nonlinear mixed-effects models were applied to describe the population PK using Monolix2024R1. Maximum concentrations (

Indexed as

Antitubercular AgentsEthambutolHIV InfectionsPyrazinamideTuberculosisAdolescentArea Under CurveChildChild, PreschoolCoinfectionFemaleHumansInfantMaleAntitubercular AgentsEthambutolPyrazinamideanti-tuberculosis drugsethambutolpediatricspopulation pharmacokineticspyrazinamide

Identifiers

PMID41770228
PMCPMC13041307

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.