ArticleJACC. Case reports2026
Pulmonary Carcinoid and Left-Sided Heart Disease: When Carcinoid Goes Left.
Article in JACC. Case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Multivalvular Carcinoid Heart Disease: The Role of Echocardiography in Diagnosis and Selection for Heterotopic Bicaval Valve Implantation.Diagnostics (Basel, Switzerland) · 2026Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCarcinoid heart disease (CHD) is a rare cause of valvular dysfunction due to exposure to vasoactive substances secreted by neuroendocrine tumors. Left-sided involvement of the mitral and aortic valves is uncommon. CASE SUMMARY: A 53-year-old woman presented with progressive dyspnea and severe mitral regurgitation with moderate stenosis and moderate aortic regurgitation. N-terminal pro-B-type natriuretic peptide level was elevated, while other biomarkers of carcinoid activity were negative. Echocardiography demonstrated characteristic valvular thickening and restricted leaflet motion. The patient had a known well-differentiated pulmonary carcinoid without metastatic disease. After multidisciplinary discussion, bioprosthetic mitral and aortic valve replacement was performed, with histological confirmation of CHD. Subsequent pulmonary lobectomy was uneventful. DISCUSSION: Diagnosis of left-sided CHD can be challenging given the limited sensitivity of traditional biomarkers. TAKE-HOME MESSAGES: Left-sided CHD is rare but may occur in the setting of pulmonary carcinoid. Biomarkers in CHD may be negative, further complicating diagnosis.
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