Evidence map›Paper›PMID 41769994›Full record

ReviewJournal of virology2026

Challenges in developing broad-spectrum viral attachment inhibitors targeting heparan sulfates and sialic acids.

Valeria Cagno

Abstract readReview
In one paragraph

Review in Journal of virology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Valeria CagnoInstitute of Microbiology, Universite de Lausanne and University Hospital of Lausanne, Lausanne, Switzerland.ORCID 0000-0002-5597-334X

Funding

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (SNF) CR00-5-239815
6 · The paper itself

Abstract

Many distinct viruses exploit cell surface glycans, particularly heparan sulfates and sialic acids, as initial attachment factors to facilitate entry into host cells. Because these interactions are highly conserved across diverse viral families, they have long been viewed as attractive targets for the development of broad-spectrum antiviral strategies. Over the past decades, numerous approaches have attempted to block these early binding events, including genetic or enzymatic removal of glycans from the cell surface, masking of cell surface glycans, the use of engineered decoy receptors, and the development of multivalent inhibitors. Despite promising

Indexed as

Antiviral AgentsHeparan SulfateSialic AcidsVirus AttachmentVirusesAnimalsHumansVirus InternalizationAntiviral AgentsHeparan SulfateSialic Acidsantiviralbroad spectrumentryglycomimeticheparan sulfatesreceptorsialic acid

Identifiers

PMID41769994
PMCPMC13098229

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.