Trial reportAnnals of African medicine2026
Assessing the Outcomes of Anterior Cruciate Ligament Reconstruction with or without the use of Antibiotic Solution in Graft Preparation: A Randomized Control Trial.
Trial report in Annals of African medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundReconstruction of ligament injuries, particularly the anterior cruciate ligament, is a widely accepted approach for restoring knee function in anterior cruciate ligament (ACL) deficiency; however, postoperative infections remain a serious complication. Presoaking grafts in antibiotic solutions offers protective benefits against infection by providing local antibiotic prophylaxis without affecting graft integrity. No high-quality RCTs in India have evaluated this infection prevention method. METHODOLOGY: In this prospective RCT at a tertiary center, 76 patients with complete ACL tears were allocated to presoaking of ACL grafts in either vancomycin solution (500 mg/100 mL saline for 10-15 min) in the experimental group or presoaking of ACL grafts in normal saline in the control group before implantation. A simple randomization technique using sealed opaque envelopes ensured unbiased allocation. The primary outcome was postoperative infection measured via C-reactive protein levels postoperatively to monitor the inflammatory response. Functional outcomes were assessed using the International Knee Documentation Committee (IKDC) and Lysholm Knee score at 6 months.
resultsThis study aims to evaluate the effectiveness of vancomycin presoaking of ACL grafts in reducing postoperative infection rates in patients undergoing ACLR. The vancomycin presoaked ACL grafts group ( n = 38) had 0% infection versus 5.26% in the saline presoaked ACL grafts group ( n = 38) ( P = 0.152). No graft failures occurred in both groups. Mean IKDC scores were 87.02 ± 6.75 in the vancomycin presoaked grafts group versus 87.19 ± 6.24 in the saline presoaked grafts group ( P = 0.838), and mean Lysholm scores were 83.68 ± 7.66 in the vancomycin presoaked grafts group versus 86.47 ± 6.38 in the saline presoaked grafts group ( P > 0.05), respectively.
conclusionsVancomycin presoaking of ACL grafts is safe and shows a trend towards lower infection risk without adverse effects on graft performance or recovery.
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