Evidence map›Paper›PMID 41769737›Full record

ArticleJournal of the American Chemical Society2026

Pyridoxal 5'-Phosphate-Dependent Enzymatic Decarboxylative Annulation.

Weiwei Chai, Shenggan Luo, Wenhui Xi, Xu He, Ting Zhang, Yike Zou, Yang Hai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Chemical Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Weiwei ChaiDepartment of Chemistry and Biochemistry, University of California Santa Barbara, Santa Barbara, California 93106, United States.
Shenggan LuoSchool of Pharmaceutical Sciences, Shanghai Jiao Tong University, Shanghai 200240, China.
Wenhui XiDepartment of Chemistry and Biochemistry, University of California Santa Barbara, Santa Barbara, California 93106, United States.
Xu HeDepartment of Chemistry and Biochemistry, University of California Santa Barbara, Santa Barbara, California 93106, United States.
Ting ZhangSchool of Pharmaceutical Sciences, Shanghai Jiao Tong University, Shanghai 200240, China.
Yike ZouSchool of Pharmaceutical Sciences, Shanghai Jiao Tong University, Shanghai 200240, China.ORCID 0000-0003-4380-7827
Yang HaiDepartment of Chemistry and Biochemistry, University of California Santa Barbara, Santa Barbara, California 93106, United States.ORCID 0000-0002-2039-5367

Funding

Understanding the specificity and non-native catalytic activity of PLP-dependent enzymesR35GM151205 · NIGMS · UNIVERSITY OF CALIFORNIA SANTA BARBARA · PI Yang Hai · 2023 to 2026
$1.8M
NIGMS NIH HHS R35 GM151205
6 · The paper itself

Abstract

Pyridoxal 5'-phosphate (PLP)-dependent enzymes are among the most versatile biocatalysts, yet transformations involving the Cγ-nucleophilic vinylglycine quinonoid (VGQ) intermediate remain exceptionally rare. Understanding the untapped reactivity of VGQ could open new avenues for developing PLP-dependent biocatalysts. Here, we establish a biocatalytic platform that artificially accesses and exploits the reactivity of this high-energy intermediate. By reprogramming SphA, a PLP-dependent enzyme that natively catalyzes decarboxylative Claisen condensation, to generate VGQ

Indexed as

Pyridoxal PhosphateBiocatalysisCarboxy-LyasesDecarboxylationModels, MolecularCarboxy-LyasesPyridoxal Phosphate

Identifiers

PMID41769737
PMCPMC13005724

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.