Evidence map›Paper›PMID 41769694›Full record

ArticleFrontiers in pharmacology2026

Promising synergistic interactions and mixture optimization of safranal, crocin, and crocetin from Moroccan

Abdellah Baraich, Ibrahim Sadougui, Amine Elbouzidi, Mounir Haddou, Mohamed Taibi, Abdessamad Beraich, Fatima Zahrae El Moussaoui, Omer M Almarfadi, Ramzi A Mothana, Mohammed F Hawwal and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Abdellah BaraichLaboratoire de Bioressources, Biotechnologie, Ethnopharmacologie et Santé (LBBES), Faculté des Sciences d'Oujda (FSO), Université Mohammed Premier (UMP), Oujda, Morocco.
Ibrahim SadouguiLaboratoire de Bioressources, Biotechnologie, Ethnopharmacologie et Santé (LBBES), Faculté des Sciences d'Oujda (FSO), Université Mohammed Premier (UMP), Oujda, Morocco.
Amine ElbouzidiLaboratoire d'Amélioration des Productions Agricoles, Biotechnologie et Environnement (LAPABE), Faculté des Sciences (FS), Université Mohammed Premier (UMP), Oujda, Morocco.
Mounir HaddouLaboratoire d'Amélioration des Productions Agricoles, Biotechnologie et Environnement (LAPABE), Faculté des Sciences (FS), Université Mohammed Premier (UMP), Oujda, Morocco.
Mohamed TaibiLaboratoire d'Amélioration des Productions Agricoles, Biotechnologie et Environnement (LAPABE), Faculté des Sciences (FS), Université Mohammed Premier (UMP), Oujda, Morocco.
Abdessamad BeraichLaboratoire Environnement et Chimie Appliquée (LCAE), Equipe: Chimie Physique des Ressources Naturelles et des Procédés, Département de Chimie, Faculté des Sciences d'Oujda (FSO), Université Mohammed Premier (UMP), Oujda, Morocco.
Fatima Zahrae El MoussaouiLaboratoire de Bioressources, Biotechnologie, Ethnopharmacologie et Santé (LBBES), Faculté des Sciences d'Oujda (FSO), Université Mohammed Premier (UMP), Oujda, Morocco.
Omer M AlmarfadiDepartment of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Ramzi A MothanaDepartment of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Mohammed F HawwalDepartment of Pharmacognosy, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Abdeslam AsehraouLaboratoire de Bioressources, Biotechnologie, Ethnopharmacologie et Santé (LBBES), Faculté des Sciences d'Oujda (FSO), Université Mohammed Premier (UMP), Oujda, Morocco.
Mohamed AddiLaboratoire d'Amélioration des Productions Agricoles, Biotechnologie et Environnement (LAPABE), Faculté des Sciences (FS), Université Mohammed Premier (UMP), Oujda, Morocco.
François MesnardBIOPI-BioEcoAgro UMRT 1158 INRAE Université de Picardie Jules Verne, Amiens, France.
Bassem JaouadiLaboratoire des Biotechnologies Microbiennes et Enzymatiques et Biomolécules (LBMEB), Centre de Biotechnologie de Sfax (CBS), Université de Sfax (USF), Sfax, Tunisia.
Ennouamane SaalaouiLaboratoire de Bioressources, Biotechnologie, Ethnopharmacologie et Santé (LBBES), Faculté des Sciences d'Oujda (FSO), Université Mohammed Premier (UMP), Oujda, Morocco.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study explores the antimicrobial activity of three principal bioactive constituents of

Indexed as

antimicrobial activitycrocetincrocinCrocus sativus L.minimum inhibitory concentrationmixturedesignsafranalsynergistic interaction

Identifiers

PMID41769694
PMCPMC12947268

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.