ArticleCureus2026
Inhibition of Castration-Sensitive LNCaP, Castration-Resistant TRAMP-C2, and Bone-Metastatic C4-2B Prostate Cancer Cell Growth by an Alpha-Tomatine Tomato Extract: In Vitro and In Vivo Study.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
Currently, hormonal therapy is the main treatment option for advanced prostate cancer; however, a certain number of cases progress to metastatic, castration-resistant prostate cancer. Therefore, we designed in vitro and in vivo studies of a new molecular targeted therapy using alpha-tomatine (α-tomatine), a glycoalkaloid extracted from tomatoes, for the growth inhibition of both castration-sensitive human LNCaP and castration-resistant mouse TRAMP-C2 and metastatic human C4-2B prostate cancer cell lines. In vitro, α-tomatine supplementation showed a dose-dependent decrease in the proliferation potential of all prostate cancer cells at concentrations ranging from 1.0 to 5.0 μg/mL, as well as a decrease in migration and invasion abilities at concentrations ranging from 1.0 to 2.5 μg/mL, which was sustained throughout the 72 hours post-treatment (p < 0.050). Furthermore, flow cytometry demonstrated that α-tomatine at 2.5 μg/mL enhanced the incidence of apoptosis in TRAMP-C2 cells at 48 hours post-treatment (p < 0.010). In vivo, TRAMP-C2 cells were subcutaneously implanted in C57BL/6 mice. Then, at a 10-mm diameter, single-time intratumoral injection of 1.0 µg/body α-tomatine was performed. Longitudinal follow-up identified a time-dependent tumor growth inhibition at 3-4 (p
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