Knowledge and Perceptions of Parents and Adolescents Regarding HPV and Its Vaccine.

Background Human papillomavirus (HPV) is one of the most common sexually transmitted infections worldwide and is associated with several malignancies. Understanding parental and adolescent knowledge and perceptions regarding HPV and its vaccine is essential for improving vaccination uptake. Methods This cross-sectional study was conducted between April and May 2023 in a health center in Northern Greece. Questionnaires were completed by 151 parents and 152 adolescents aged 11-18 years. Data were analyzed using descriptive statistics and multivariable regression analyses. Results Among parents, 89.3% were aware of HPV, and 82.8% were generally in favor of vaccination. Higher HPV knowledge scores were observed among women and participants with higher educational levels (p < 0.001 and p = 0.001, respectively). Among adolescents, 63.6% expressed intention to receive the HPV vaccine. Female gender (odds ratio (OR) = 2.16, 95% confidence interval (CI): 1.05-4.46) and discussion with parents about sexually transmitted diseases (STDs) were independently associated with vaccination intention. Older age was positively associated with higher HPV knowledge scores among adolescents (p < 0.001). Conclusions Both parents and adolescents demonstrated substantial awareness of HPV infection and its prevention. Parental communication and adolescents' gender were important factors associated with vaccination intention, highlighting the need for targeted educational interventions to enhance HPV vaccine uptake.