ReviewNeuro-oncology advances2026
Single-cell advances in the investigation of the pathogenesis and treatment of brain metastasis.
Review in Neuro-oncology advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Special Issue: The Evolving Landscape of Single-Cell Genomics in CNS and PNS Oncology.Neuro-oncology advances · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Brain metastasis remains a significant cause of morbidity and mortality for cancer patients with limited treatment options. Single-cell RNA-seq has greatly expanded our ability to study cancer and metastasis, particularly in our assessment of tumor heterogeneity and the tumor microenvironment. In recent years, there have been several single-cell studies that have applied this technology to brain metastasis. These studies have described transcriptional characteristics of brain metastatic tumor cells and characterized immune cell changes as well as contributions of vascular and stromal cells to the brain metastatic microenvironment. This review article summarizes these studies, how they contribute to our knowledge of the molecular and cellular steps that occur in brain metastasis and in response to therapy, and how they suggest promise for future treatments.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.