Evidence map›Paper›PMID 41769414›Full record

ReviewNeuro-oncology advances2026

Current landscape of single-cell genomics in meningioma.

Yosef Ellenbogen, Alexander P Landry, Leeor S Yefet, Andrew Ajisebutu, Chloe Gui, Phooja Persaud, Ramneet Kaloti, Farshad Nassiri

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neuro-oncology advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yosef EllenbogenPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.ORCID https://orcid.org/0000-0003-1390-1361
Alexander P LandryPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Leeor S YefetPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Andrew AjisebutuPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Chloe GuiPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Phooja PersaudPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Ramneet KalotiPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.
Farshad NassiriPrincess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Meningiomas are the most common primary intracranial tumor in adults. Traditional bulk genomic and histopathological analyses have provided valuable insights into meningioma biology. Recent advances in single-cell sequencing technologies have enabled the comprehensive study of a tumor's transcriptome and epigenome at a single-cell resolution, along with spatially resolved data and functional genomics approaches. These strategies allow for the profiling of complex intratumoral and intertumoral heterogeneity, the identification of gene regulatory networks, and the characterization of distinct cell populations within the tumor microenvironment that drive tumor behavior. In this review, we examine the current landscape of single-cell omics in meningioma research and highlight opportunities for future discovery.

Indexed as

functional genomicsmeningiomamulti-omicssingle-cell RNA sequencingtumor heterogeneitytumor microenvironment

Identifiers

PMID41769414
PMCPMC12946768

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.